Pharmacokinetics of cancer therapeutics and energy balance: the role of diet intake, energy expenditure, and body composition

Sarah A. Purcell, Dieuwertje E. Kok, Tyler Ketterl, Miriam B. Garcia, Lenat Joffe, Justin C. Brown, Christina M. Dieli-Conwright, Grant R. Williams*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

4 Citations (Scopus)

Abstract

Energy balance accounts for an individual's energy intake, expenditure, and storage. Each aspect of energy balance has implications for the pharmacokinetics of cancer treatments and may impact an individual's drug exposure and subsequently its tolerance and efficacy. However, the integrated effects of diet, physical activity, and body composition on drug absorption, metabolism, distribution, and excretion are not yet fully understood. This review examines the existing literature on energy balance, specifically the role of dietary intake and nutritional status, physical activity and energy expenditure, and body composition on the pharmacokinetics of cancer therapeutics. As energy balance and pharmacokinetic factors can be influenced by age-related states of metabolism and comorbidities, this review also explores the age-related impact of body composition and physiologic changes on pharmacokinetics among pediatric and older adult populations with cancer.

Original languageEnglish
Pages (from-to)3-11
Number of pages9
JournalJournal of the National Cancer Institute. Monographs
Volume2023
Issue number61
DOIs
Publication statusPublished - 4 May 2023

Fingerprint

Dive into the research topics of 'Pharmacokinetics of cancer therapeutics and energy balance: the role of diet intake, energy expenditure, and body composition'. Together they form a unique fingerprint.

Cite this