Perspectives for the Industrial Enzymatic Production of Glycosides

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Abstract

Glycosides are of commercial interest for industry in general and specifically for the pharmaceutical and food industry. Currently chemical preparation of glycosides will not meet EC food regulations, and therefore chemical preparation of glycosides is not applicable in the food industry. Thus, enzyme-catalyzed reactions are a good alternative. However, until now the low yields obtained by enzymatic methods prevent the production of glycosides on a commercial scale. Therefore, high yields should be established by a combination of optimum reaction conditions and continuous removal of the product. Unfortunately, a bioreactor for the commercial scale production of glycosides is not available. The aim of this article is to discuss the literature with respect to enzymatic production of glycosides and the design of an industrially viable bioreactor system.
Original languageEnglish
Pages (from-to)1391-1402
Number of pages11
JournalBiotechnology Progress
Volume19
Issue number5
DOIs
Publication statusPublished - 2003

Keywords

  • immobilized beta-galactosidase
  • archaeon pyrococcus-furiosus
  • organic 2-phase system
  • packed-bed reactor
  • membrane reactor
  • alkyl glycosides
  • nonisothermal conditions
  • neisseria-polysaccharea
  • catalytic mechanism
  • glucoside synthesis

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