Peroxisome proliferator-activated receptor a target genes

S.J. Mandard, M.R. Müller, A.H. Kersten

Research output: Contribution to journalArticleAcademicpeer-review

712 Citations (Scopus)

Abstract

Peroxisome proliferator-activated receptors (PPARs) are nuclear proteins that belong to the superfamily of nuclear hormone receptors. They mediate the effects of small lipophilic compounds such as long-chain fatty acids and their derivatives on transcription of genes commonly called PPAR target genes. Here we review the involvement of PPAR in peroxisomal and mitochondrial fatty acid oxidation, microsomal fatty acid hydroxylation, lipoprotein, bile and amino acid metabolism, glucose homeostasis, biotransformation, inflammation control, hepato-carcinogenesis and other pathways, through a detailed analysis of the different known or putative PPAR target genes.
Original languageEnglish
Pages (from-to)393-416
JournalCellular and Molecular Life Sciences
Volume61
Issue number4
DOIs
Publication statusPublished - 2004

Keywords

  • ppar-gamma activators
  • fatty-acid oxidation
  • apolipoprotein-a-i
  • phospholipid transfer protein
  • acyl-coa oxidase
  • cholesterol 7-alpha-hydroxylase gene
  • pyruvate-dehydrogenase kinase-4
  • rat hydratase-dehydrogenase
  • vascular endothelial-cells
  • s-transferase

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