Peptide-Mediated Blood-Brain Barrier Transport of Polymersomes

J.V. Georgieva; R.P. Brinkhuis; K. Stojanov; C.A.G.M. Weijers; H. Zuilhof; F.P.J.T. Rutjes; D. Hoekstra; J.C.M. van Hest; I.S. Zuhorn

doi:10.1002/anie.201202001

Peptide-Mediated Blood-Brain Barrier Transport of Polymersomes

J.V. Georgieva, R.P. Brinkhuis, K. Stojanov, C.A.G.M. Weijers, H. Zuilhof, F.P.J.T. Rutjes, D. Hoekstra, J.C.M. van Hest, I.S. Zuhorn

Research output: Contribution to journal › Article › Academic › peer-review

80 Citations (Scopus)

Abstract

A polymeric nanocarrier: Polymersomes tagged with a dodecamer peptide that recognizes gangliosides GM1 and GT1b are shown to cross the blood–brain barrier, both in an in vitro model and in vivo (see picture). The combination of polymeric vesicles with a small GM1-binding peptide and GM1/GT1b gangliosides as targeting sites for blood–brain barrier transport is unprecedented.

Original language	English
Pages (from-to)	8339-8342
Journal	Angewandte Chemie-International Edition
Volume	51
Issue number	33
DOIs	https://doi.org/10.1002/anie.201202001
Publication status	Published - 2012

Keywords

in-vivo
biodegradable polymersomes
nervous-system
delivery
nanoparticles
therapeutics
vesicles
protein
mouse

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10.1002/anie.201202001

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title = "Peptide-Mediated Blood-Brain Barrier Transport of Polymersomes",

abstract = "A polymeric nanocarrier: Polymersomes tagged with a dodecamer peptide that recognizes gangliosides GM1 and GT1b are shown to cross the blood–brain barrier, both in an in vitro model and in vivo (see picture). The combination of polymeric vesicles with a small GM1-binding peptide and GM1/GT1b gangliosides as targeting sites for blood–brain barrier transport is unprecedented.",

keywords = "in-vivo, biodegradable polymersomes, nervous-system, delivery, nanoparticles, therapeutics, vesicles, protein, mouse",

author = "J.V. Georgieva and R.P. Brinkhuis and K. Stojanov and C.A.G.M. Weijers and H. Zuilhof and F.P.J.T. Rutjes and D. Hoekstra and {van Hest}, J.C.M. and I.S. Zuhorn",

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pages = "8339--8342",

journal = "Angewandte Chemie-International Edition",

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publisher = "Wiley-VCH Verlag",

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Peptide-Mediated Blood-Brain Barrier Transport of Polymersomes. / Georgieva, J.V.; Brinkhuis, R.P.; Stojanov, K.; Weijers, C.A.G.M.; Zuilhof, H.; Rutjes, F.P.J.T.; Hoekstra, D.; van Hest, J.C.M.; Zuhorn, I.S.

In: Angewandte Chemie-International Edition, Vol. 51, No. 33, 2012, p. 8339-8342.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Peptide-Mediated Blood-Brain Barrier Transport of Polymersomes

AU - Georgieva, J.V.

AU - Brinkhuis, R.P.

AU - Stojanov, K.

AU - Weijers, C.A.G.M.

AU - Zuilhof, H.

AU - Rutjes, F.P.J.T.

AU - Hoekstra, D.

AU - van Hest, J.C.M.

AU - Zuhorn, I.S.

PY - 2012

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N2 - A polymeric nanocarrier: Polymersomes tagged with a dodecamer peptide that recognizes gangliosides GM1 and GT1b are shown to cross the blood–brain barrier, both in an in vitro model and in vivo (see picture). The combination of polymeric vesicles with a small GM1-binding peptide and GM1/GT1b gangliosides as targeting sites for blood–brain barrier transport is unprecedented.

AB - A polymeric nanocarrier: Polymersomes tagged with a dodecamer peptide that recognizes gangliosides GM1 and GT1b are shown to cross the blood–brain barrier, both in an in vitro model and in vivo (see picture). The combination of polymeric vesicles with a small GM1-binding peptide and GM1/GT1b gangliosides as targeting sites for blood–brain barrier transport is unprecedented.

KW - in-vivo

KW - biodegradable polymersomes

KW - nervous-system

KW - delivery

KW - nanoparticles

KW - therapeutics

KW - vesicles

KW - protein

KW - mouse

U2 - 10.1002/anie.201202001

DO - 10.1002/anie.201202001

M3 - Article

VL - 51

SP - 8339

EP - 8342

JO - Angewandte Chemie-International Edition

JF - Angewandte Chemie-International Edition

SN - 1433-7851

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