Peptide-Mediated Blood-Brain Barrier Transport of Polymersomes

J.V. Georgieva, R.P. Brinkhuis, K. Stojanov, C.A.G.M. Weijers, H. Zuilhof, F.P.J.T. Rutjes, D. Hoekstra, J.C.M. van Hest, I.S. Zuhorn

Research output: Contribution to journalArticleAcademicpeer-review

80 Citations (Scopus)

Abstract

A polymeric nanocarrier: Polymersomes tagged with a dodecamer peptide that recognizes gangliosides GM1 and GT1b are shown to cross the blood–brain barrier, both in an in vitro model and in vivo (see picture). The combination of polymeric vesicles with a small GM1-binding peptide and GM1/GT1b gangliosides as targeting sites for blood–brain barrier transport is unprecedented.
Original languageEnglish
Pages (from-to)8339-8342
JournalAngewandte Chemie-International Edition
Volume51
Issue number33
DOIs
Publication statusPublished - 2012

Keywords

  • in-vivo
  • biodegradable polymersomes
  • nervous-system
  • delivery
  • nanoparticles
  • therapeutics
  • vesicles
  • protein
  • mouse

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