Pasteurella multocida-toxin induced atrophic rhinitis in piglets

P.M. van Diemen

Research output: Thesisinternal PhD, WUAcademic

Abstract

<br/>Progressive atrophic rhinitis (AR) is a complex of disease symptoms caused by infection with toxigenic <em>Pasteurella multocida</em> . Environmental and animal factors contribute to the severity of the disease. Their impact and relationship with severity of disease are inadequately understood and remain to be quantified in their effects. In this thesis, two areas of interest in atrophic rhinitis have been studied. A challenge model with <em>Pasteurella multocida</em> derived toxin (Pm-T) to mimic the disease was developed. Next, the impact of some aspects of climatic environment and the relationship with the severity of AR on health and metabolism of piglets were studied. Furthermore, investigations on the role of the immune system in atrophic rhinitis have been conducted with emphasis on mechanisms underlying the apparent lack of conventional (classic) immune responses to Pm-T. The Pm-T challenge resulted mainly in a lower food intake with concomitant lower weight gain, and in a reduced heat production caused by decreased activity of the pigs. Immunological features of Pm-T suggest T cell involvement in the pathogenesis of AR. Though the immune responses during AR remain far from understood, it is hypothesized that AR has autoimmune like features, with Pm-T triggering T cells to initiate destruction of nasal bony tissue.
LanguageEnglish
QualificationDoctor of Philosophy
Awarding Institution
Supervisors/Advisors
  • Noordhuizen, J.P.T.M., Promotor, External person
  • Parmentier, Henk, Promotor
  • Schrama, Johan, Promotor
Award date24 Apr 1995
Place of PublicationS.l.
Publisher
Print ISBNs9789054853824
Publication statusPublished - 1995

Fingerprint

rhinitis
Pasteurella multocida
piglets
toxins
disease severity
T-lymphocytes
immune response
heat production
signs and symptoms (animals and humans)
immune system
food intake
pathogenesis
weight gain
swine
metabolism
infection

Keywords

  • veterinary science
  • piglets
  • bordetella
  • atrophic rhinitis
  • pasteurella

Cite this

van Diemen, P. M. (1995). Pasteurella multocida-toxin induced atrophic rhinitis in piglets. S.l.: Van Diemen.
van Diemen, P.M.. / Pasteurella multocida-toxin induced atrophic rhinitis in piglets. S.l. : Van Diemen, 1995. 152 p.
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title = "Pasteurella multocida-toxin induced atrophic rhinitis in piglets",
abstract = "Progressive atrophic rhinitis (AR) is a complex of disease symptoms caused by infection with toxigenic Pasteurella multocida . Environmental and animal factors contribute to the severity of the disease. Their impact and relationship with severity of disease are inadequately understood and remain to be quantified in their effects. In this thesis, two areas of interest in atrophic rhinitis have been studied. A challenge model with Pasteurella multocida derived toxin (Pm-T) to mimic the disease was developed. Next, the impact of some aspects of climatic environment and the relationship with the severity of AR on health and metabolism of piglets were studied. Furthermore, investigations on the role of the immune system in atrophic rhinitis have been conducted with emphasis on mechanisms underlying the apparent lack of conventional (classic) immune responses to Pm-T. The Pm-T challenge resulted mainly in a lower food intake with concomitant lower weight gain, and in a reduced heat production caused by decreased activity of the pigs. Immunological features of Pm-T suggest T cell involvement in the pathogenesis of AR. Though the immune responses during AR remain far from understood, it is hypothesized that AR has autoimmune like features, with Pm-T triggering T cells to initiate destruction of nasal bony tissue.",
keywords = "diergeneeskunde, biggen, bordetella, atrofische rhinitis, pasteurella, veterinary science, piglets, bordetella, atrophic rhinitis, pasteurella",
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van Diemen, PM 1995, 'Pasteurella multocida-toxin induced atrophic rhinitis in piglets', Doctor of Philosophy, S.l..

Pasteurella multocida-toxin induced atrophic rhinitis in piglets. / van Diemen, P.M.

S.l. : Van Diemen, 1995. 152 p.

Research output: Thesisinternal PhD, WUAcademic

TY - THES

T1 - Pasteurella multocida-toxin induced atrophic rhinitis in piglets

AU - van Diemen, P.M.

N1 - WU thesis 1916 Proefschrift Wageningen

PY - 1995

Y1 - 1995

N2 - Progressive atrophic rhinitis (AR) is a complex of disease symptoms caused by infection with toxigenic Pasteurella multocida . Environmental and animal factors contribute to the severity of the disease. Their impact and relationship with severity of disease are inadequately understood and remain to be quantified in their effects. In this thesis, two areas of interest in atrophic rhinitis have been studied. A challenge model with Pasteurella multocida derived toxin (Pm-T) to mimic the disease was developed. Next, the impact of some aspects of climatic environment and the relationship with the severity of AR on health and metabolism of piglets were studied. Furthermore, investigations on the role of the immune system in atrophic rhinitis have been conducted with emphasis on mechanisms underlying the apparent lack of conventional (classic) immune responses to Pm-T. The Pm-T challenge resulted mainly in a lower food intake with concomitant lower weight gain, and in a reduced heat production caused by decreased activity of the pigs. Immunological features of Pm-T suggest T cell involvement in the pathogenesis of AR. Though the immune responses during AR remain far from understood, it is hypothesized that AR has autoimmune like features, with Pm-T triggering T cells to initiate destruction of nasal bony tissue.

AB - Progressive atrophic rhinitis (AR) is a complex of disease symptoms caused by infection with toxigenic Pasteurella multocida . Environmental and animal factors contribute to the severity of the disease. Their impact and relationship with severity of disease are inadequately understood and remain to be quantified in their effects. In this thesis, two areas of interest in atrophic rhinitis have been studied. A challenge model with Pasteurella multocida derived toxin (Pm-T) to mimic the disease was developed. Next, the impact of some aspects of climatic environment and the relationship with the severity of AR on health and metabolism of piglets were studied. Furthermore, investigations on the role of the immune system in atrophic rhinitis have been conducted with emphasis on mechanisms underlying the apparent lack of conventional (classic) immune responses to Pm-T. The Pm-T challenge resulted mainly in a lower food intake with concomitant lower weight gain, and in a reduced heat production caused by decreased activity of the pigs. Immunological features of Pm-T suggest T cell involvement in the pathogenesis of AR. Though the immune responses during AR remain far from understood, it is hypothesized that AR has autoimmune like features, with Pm-T triggering T cells to initiate destruction of nasal bony tissue.

KW - diergeneeskunde

KW - biggen

KW - bordetella

KW - atrofische rhinitis

KW - pasteurella

KW - veterinary science

KW - piglets

KW - bordetella

KW - atrophic rhinitis

KW - pasteurella

M3 - internal PhD, WU

SN - 9789054853824

PB - Van Diemen

CY - S.l.

ER -

van Diemen PM. Pasteurella multocida-toxin induced atrophic rhinitis in piglets. S.l.: Van Diemen, 1995. 152 p.