Partial restoration of normal intestinal microbiota in morbidly obese women six months after bariatric surgery

Jukka Koffert, Leo Lahti, Lotta Nylund, Seppo Salminen, Jarna C. Hannukainen, Paulina Salminen, Willem M. De Vos, Pirjo Nuutila*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

We studied the impact of bariatric surgery on the intestinal microbiota of morbidly obese study subjects. A total of 13 morbidly obese women (five of which had type 2 diabetes) and 14 healthy age- and gender-matched controls were recruited and the microbiota composition of fecal samples were determined by using a phylogenetic microarray. Sampling of the patients took place just one month before and 6 months after the operation. Within six months after bariatric surgery, the obese subjects had lost on average a quarter of their weight whereas four of the five of the diabetic subjects were in remission. Bariatric surgery was associated with an increased microbial community richness and Bacteroidetes/Firmicutes ratio. In addition, we observed an increased relative abundance of facultative anaerobes, such as Streptococcus spp., and a reduction in specific butyrate-producing Firmicutes. The observed postoperative alterations in intestinal microbiota reflect adaptation to the changing conditions in the gastrointestinal tract, such as energy restriction and the inability to process fiber-rich foods after bariatric surgery.

Original languageEnglish
Article numbere10442
JournalPeerJ
Volume8
DOIs
Publication statusPublished - 26 Nov 2020

Keywords

  • Bariatric surgery
  • Clinical trial
  • Fecal microbiota
  • Obesity
  • Type 2 diabetes

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