TY - JOUR
T1 - Oxidative stress, and iron and antioxidant status in elderly men: differences between the Mediterranean south (Crete) and northern Europe (Zutphen)
AU - Buijsse, B.
AU - Feskens, E.J.M.
AU - Moschandreas, J.
AU - Jansen, E.H.
AU - Jacobs, D.R.
AU - Kafatos, A.
AU - Kok, F.J.
AU - Kromhout, D.
PY - 2007
Y1 - 2007
N2 - Background: Oxidative stress may accelerate ageing and increase the risk of chronic diseases, such as coronary heart disease (CHD). We assessed differences in oxidative stress, and iron and antioxidant status between elderly men living in Mediterranean southern Europe (Crete, Greece) and northern Europe (Zutphen, The Netherlands).
Design: A cross-sectional study using data from two cohorts of the Seven Countries Study.
Methods: Non-fasting blood samples were drawn in 2000 from 105 men from Crete and 139 men from Zutphen, all aged 79 years or over. All assays were performed in the same laboratory.
Results: After multiple adjustments, serum levels of the markers of oxidative stress were lower in Cretan men than in men from Zutphen, as indicated by lower mean levels of hydroperoxides (33.2 versus 57.3 [mu]mol/l; P=0.005) and gamma-glutamyltransferase (20.3 versus 26.1 U/l; P=0.003). The most pronounced difference in iron status was a twofold lower mean serum ferritin level in Cretan men (69.8 [mu]g/l) compared with men from Zutphen (134.2 [mu]g/l; P
AB - Background: Oxidative stress may accelerate ageing and increase the risk of chronic diseases, such as coronary heart disease (CHD). We assessed differences in oxidative stress, and iron and antioxidant status between elderly men living in Mediterranean southern Europe (Crete, Greece) and northern Europe (Zutphen, The Netherlands).
Design: A cross-sectional study using data from two cohorts of the Seven Countries Study.
Methods: Non-fasting blood samples were drawn in 2000 from 105 men from Crete and 139 men from Zutphen, all aged 79 years or over. All assays were performed in the same laboratory.
Results: After multiple adjustments, serum levels of the markers of oxidative stress were lower in Cretan men than in men from Zutphen, as indicated by lower mean levels of hydroperoxides (33.2 versus 57.3 [mu]mol/l; P=0.005) and gamma-glutamyltransferase (20.3 versus 26.1 U/l; P=0.003). The most pronounced difference in iron status was a twofold lower mean serum ferritin level in Cretan men (69.8 [mu]g/l) compared with men from Zutphen (134.2 [mu]g/l; P
KW - gamma-glutamyl-transferase
KW - improves endothelial function
KW - coronary-artery disease
KW - cardiovascular mortality
KW - heart-disease
KW - risk
KW - hypertension
KW - genotype
KW - adults
U2 - 10.1097/HJR.0b013e3280111e41
DO - 10.1097/HJR.0b013e3280111e41
M3 - Article
SN - 1741-8267
VL - 14
SP - 495
EP - 500
JO - European Journal of Cardiovascular Prevention and Rehabilitation
JF - European Journal of Cardiovascular Prevention and Rehabilitation
IS - 4
ER -