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Abstract
Coacervate-core micelles are considered promising materials for several applications, from catalysis to drug delivery. However, oxidant-responsive coacervate-core micelles, able to undergo structural changes upon specific oxidation stimuli, are not well reported. Here, we present a novel ferrocene–dipicolinic acid derivative as redox-responsive subcomponent to be incorporated in cyclodextrin-based coacervate core micelles, C4Ms, with tuneable core structure and responsiveness towards H2O2 treatment. The Fc-C4Ms are formed combining three orthogonal supramolecular interactions, namely (i) metal-to-ligand coordination between europium(III) ions and dipicolinic acid molecules, (ii) host-guest interaction between beta cyclodextrins and ferrocenes and (iii) electrostatic coacervation interaction. The micelle stability against oxidation can be controlled by varying three main parameters: (a) the core-unit structure, from monomeric metal complexes to supramolecular oligomers, (b) the H2O2 equivalents and c) the ratio between redox-responsive and non-redox-responsive bislinker. The H2O2-responsive ferrocene-based systems might have an interesting application, e.g. reactive oxygen species-mediated drug delivery.
Original language | English |
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Pages (from-to) | 30-38 |
Journal | Supramolecular Chemistry |
Volume | 32 |
Issue number | 1 |
Early online date | 5 Nov 2019 |
DOIs | |
Publication status | Published - Feb 2020 |
Keywords
- complex coacervate core micelles
- cyclodextrin
- ferrocene
- Host-guest
- stimuli-responsive
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Dive into the research topics of 'Oxidant-responsive ferrocene-based cyclodextrin complex coacervate core micelles'. Together they form a unique fingerprint.Projects
- 1 Finished
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ResMoSys: Multi-Stimuli Responsive Molecular Systems and Materials
1/01/15 → 31/12/18
Project: EU research project