Although staple crops do not survive extended periods of drought, their seeds possess desiccation tolerance (DT), as they survive almost complete dehydration (desiccation) during the late maturation phase of development. Resurrection plants are plant species whose seeds and vegetative tissues are desiccation tolerant. Vegetative DT first arose with the transition from aquatic to terrestrial life forms, but it was lost as plants acquired mechanisms for drought resistance. DT was then confined to seeds, spores, and pollen grains. We review evidence suggesting that angiosperm resurrection plants have reactivated the seed DT program in vegetative tissues. Novel omics technologies are providing a better understanding of the changes necessary for this reactivation and may aid in the development of crop varieties that are better able to survive extreme drought conditions.