Origin of the membrane compartment for cowpea mosaic virus RNA replication

J.E. Carette

Research output: Thesisinternal PhD, WU

Abstract

<p>Replication of many positive-stranded RNA viruses takes place in association with intracellular membranes. Often these membranes are induced upon infection by vesiculation or rearrangement of membranes from different organelles including the early and late endomembrane system. Upon infection of cowpea cells with cowpea mosaic virus (CPMV) typical cytopathological structures are formed, which consist of an amorphous matrix of electron-dense material traversed by rays of small membranous vesicles. This thesis describes the studies that were undertaken to define the cellular components involved in the establishment of the site of viral RNA replication consisting of vesiculated membranes and electron-dense material. Furthermore, the role of individual viral proteins as well as host proteins in this process was investigated.</p>
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • Wageningen University
Supervisors/Advisors
  • van Kammen, A., Promotor, External person
  • Wellink, J., Promotor, External person
Award date1 Feb 2002
Place of PublicationS.l.
Print ISBNs9789058085573
Publication statusPublished - 2002

Keywords

  • cowpea mosaic virus
  • dna replication
  • membranes
  • vigna unguiculata
  • cowpeas
  • vesicles
  • viral replication
  • plant diseases

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