Organoids as a research tool in animal breeding and nutrition

L.M.G. Verschuren, D. Schokker, S. Verstringe, L. Kruijt, A.A.C. de Wit, E.G.T. van der Valk, S.K. Kar, E.D. Ellen

Research output: Chapter in Book/Report/Conference proceedingConference paperAcademic

Abstract

In vitro miniaturized and simplified three-dimensional versions of an organ, commonly known as organoids, are an important innovative key technology in human and, more recently, animal research. So far, the in vitro organoid system has been applied on a small number of animals in a research setting. However, to apply the in vitro organoid system on a larger scale for industrial purposes, a high throughput system needs to be developed. The major aim of this research is to pave the way for a high throughput in vitro organoid system of the pig intestinal tract to be used in animal breeding, nutrition, and health. We developed high throughput tools to generate organoids from pig intestines on a large scale. We also looked at different applications addressing intestinal functionality, which allow to accurately phenotype animals for complex traits. Organoid research enables animal breeding companies to switch more quickly towards less animal testing.
Original languageEnglish
Title of host publicationProceedings of 12th World Congress on Genetics Applied to Livestock Production (WCGALP)
Subtitle of host publicationTechnical and species orientated innovations in animal breeding, and contribution of genetics to solving societal challenges
EditorsR.F. Veerkamp, Y. de Haas
Place of PublicationWageningen
PublisherWageningen Academic Publishers
Pages2085-2088
Number of pages4
ISBN (Electronic)9789086869404
DOIs
Publication statusPublished - 2022

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