Organoids as a research tool in animal breeding and nutrition

L.M.G. Verschuren; D. Schokker; S. Verstringe; L. Kruijt; A.A.C. de Wit; E.G.T. van der Valk; S.K. Kar; E.D. Ellen

doi:10.3920/978-90-8686-940-4_502

Organoids as a research tool in animal breeding and nutrition

L.M.G. Verschuren, D. Schokker, S. Verstringe, L. Kruijt, A.A.C. de Wit, E.G.T. van der Valk, S.K. Kar, E.D. Ellen

Research output: Chapter in Book/Report/Conference proceeding › Conference paper › Academic

Abstract

In vitro miniaturized and simplified three-dimensional versions of an organ, commonly known as organoids, are an important innovative key technology in human and, more recently, animal research. So far, the in vitro organoid system has been applied on a small number of animals in a research setting. However, to apply the in vitro organoid system on a larger scale for industrial purposes, a high throughput system needs to be developed. The major aim of this research is to pave the way for a high throughput in vitro organoid system of the pig intestinal tract to be used in animal breeding, nutrition, and health. We developed high throughput tools to generate organoids from pig intestines on a large scale. We also looked at different applications addressing intestinal functionality, which allow to accurately phenotype animals for complex traits. Organoid research enables animal breeding companies to switch more quickly towards less animal testing.

Original language	English
Title of host publication	Proceedings of 12th World Congress on Genetics Applied to Livestock Production (WCGALP)
Subtitle of host publication	Technical and species orientated innovations in animal breeding, and contribution of genetics to solving societal challenges
Editors	R.F. Veerkamp, Y. de Haas
Place of Publication	Wageningen
Publisher	Wageningen Academic Publishers
Pages	2085-2088
Number of pages	4
ISBN (Electronic)	9789086869404
DOIs	https://doi.org/10.3920/978-90-8686-940-4_502
Publication status	Published - 2022

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.3920/978-90-8686-940-4_502Licence: CC BY

https://edepot.wur.nl/586585Licence: CC BY

LWV20025 Organoids as a research tool in animal breeding and nutrition (BO-68-001-038)
Ellen, E. (Project Leader)
1/01/21 → 31/12/23
Project: LVVN project

Cite this

Verschuren, L. M. G., Schokker, D., Verstringe, S., Kruijt, L., de Wit, A. A. C., van der Valk, E. G. T., Kar, S. K., & Ellen, E. D. (2022). Organoids as a research tool in animal breeding and nutrition. In R. F. Veerkamp, & Y. de Haas (Eds.), Proceedings of 12th World Congress on Genetics Applied to Livestock Production (WCGALP): Technical and species orientated innovations in animal breeding, and contribution of genetics to solving societal challenges (pp. 2085-2088). Article 502 Wageningen Academic Publishers. https://doi.org/10.3920/978-90-8686-940-4_502

Verschuren, L.M.G. ; Schokker, D. ; Verstringe, S. et al. / Organoids as a research tool in animal breeding and nutrition. Proceedings of 12th World Congress on Genetics Applied to Livestock Production (WCGALP): Technical and species orientated innovations in animal breeding, and contribution of genetics to solving societal challenges. editor / R.F. Veerkamp ; Y. de Haas. Wageningen : Wageningen Academic Publishers, 2022. pp. 2085-2088

@inproceedings{8f5a71f545274e008db93f8a277f526c,

title = "Organoids as a research tool in animal breeding and nutrition",

abstract = "In vitro miniaturized and simplified three-dimensional versions of an organ, commonly known as organoids, are an important innovative key technology in human and, more recently, animal research. So far, the in vitro organoid system has been applied on a small number of animals in a research setting. However, to apply the in vitro organoid system on a larger scale for industrial purposes, a high throughput system needs to be developed. The major aim of this research is to pave the way for a high throughput in vitro organoid system of the pig intestinal tract to be used in animal breeding, nutrition, and health. We developed high throughput tools to generate organoids from pig intestines on a large scale. We also looked at different applications addressing intestinal functionality, which allow to accurately phenotype animals for complex traits. Organoid research enables animal breeding companies to switch more quickly towards less animal testing.",

author = "L.M.G. Verschuren and D. Schokker and S. Verstringe and L. Kruijt and {de Wit}, A.A.C. and {van der Valk}, E.G.T. and S.K. Kar and E.D. Ellen",

year = "2022",

doi = "10.3920/978-90-8686-940-4_502",

language = "English",

pages = "2085--2088",

editor = "R.F. Veerkamp and {de Haas}, Y.",

booktitle = "Proceedings of 12th World Congress on Genetics Applied to Livestock Production (WCGALP)",

publisher = "Wageningen Academic Publishers",

address = "Netherlands",

}

Verschuren, LMG, Schokker, D, Verstringe, S, Kruijt, L, de Wit, AAC , van der Valk, EGT , Kar, SK & Ellen, ED 2022, Organoids as a research tool in animal breeding and nutrition. in RF Veerkamp & Y de Haas (eds), Proceedings of 12th World Congress on Genetics Applied to Livestock Production (WCGALP): Technical and species orientated innovations in animal breeding, and contribution of genetics to solving societal challenges., 502, Wageningen Academic Publishers, Wageningen, pp. 2085-2088. https://doi.org/10.3920/978-90-8686-940-4_502

Organoids as a research tool in animal breeding and nutrition. / Verschuren, L.M.G.; Schokker, D.; Verstringe, S. et al.
Proceedings of 12th World Congress on Genetics Applied to Livestock Production (WCGALP): Technical and species orientated innovations in animal breeding, and contribution of genetics to solving societal challenges. ed. / R.F. Veerkamp; Y. de Haas. Wageningen: Wageningen Academic Publishers, 2022. p. 2085-2088 502.

Research output: Chapter in Book/Report/Conference proceeding › Conference paper › Academic

TY - GEN

T1 - Organoids as a research tool in animal breeding and nutrition

AU - Verschuren, L.M.G.

AU - Schokker, D.

AU - Verstringe, S.

AU - Kruijt, L.

AU - de Wit, A.A.C.

AU - van der Valk, E.G.T.

AU - Kar, S.K.

AU - Ellen, E.D.

PY - 2022

Y1 - 2022

N2 - In vitro miniaturized and simplified three-dimensional versions of an organ, commonly known as organoids, are an important innovative key technology in human and, more recently, animal research. So far, the in vitro organoid system has been applied on a small number of animals in a research setting. However, to apply the in vitro organoid system on a larger scale for industrial purposes, a high throughput system needs to be developed. The major aim of this research is to pave the way for a high throughput in vitro organoid system of the pig intestinal tract to be used in animal breeding, nutrition, and health. We developed high throughput tools to generate organoids from pig intestines on a large scale. We also looked at different applications addressing intestinal functionality, which allow to accurately phenotype animals for complex traits. Organoid research enables animal breeding companies to switch more quickly towards less animal testing.

AB - In vitro miniaturized and simplified three-dimensional versions of an organ, commonly known as organoids, are an important innovative key technology in human and, more recently, animal research. So far, the in vitro organoid system has been applied on a small number of animals in a research setting. However, to apply the in vitro organoid system on a larger scale for industrial purposes, a high throughput system needs to be developed. The major aim of this research is to pave the way for a high throughput in vitro organoid system of the pig intestinal tract to be used in animal breeding, nutrition, and health. We developed high throughput tools to generate organoids from pig intestines on a large scale. We also looked at different applications addressing intestinal functionality, which allow to accurately phenotype animals for complex traits. Organoid research enables animal breeding companies to switch more quickly towards less animal testing.

U2 - 10.3920/978-90-8686-940-4_502

DO - 10.3920/978-90-8686-940-4_502

M3 - Conference paper

SP - 2085

EP - 2088

BT - Proceedings of 12th World Congress on Genetics Applied to Livestock Production (WCGALP)

A2 - Veerkamp, R.F.

A2 - de Haas, Y.

PB - Wageningen Academic Publishers

CY - Wageningen

ER -

Verschuren LMG, Schokker D, Verstringe S, Kruijt L, de Wit AAC , van der Valk EGT et al. Organoids as a research tool in animal breeding and nutrition. In Veerkamp RF, de Haas Y, editors, Proceedings of 12th World Congress on Genetics Applied to Livestock Production (WCGALP): Technical and species orientated innovations in animal breeding, and contribution of genetics to solving societal challenges. Wageningen: Wageningen Academic Publishers. 2022. p. 2085-2088. 502 doi: 10.3920/978-90-8686-940-4_502

Organoids as a research tool in animal breeding and nutrition

Abstract

UN SDGs

Access to Document

Fingerprint

Projects

LWV20025 Organoids as a research tool in animal breeding and nutrition (BO-68-001-038)

Cite this