Orchestration of floral initiation by APETALA1

K. Kaufmann, F. Wellmer, J.M. Muino, T. Ferrier, S.E. Wuest, V. Kumar, A. Serrano-Mislata, F. Madueno, P. Krajweski, E.M. Meyerowitz, G.C. Angenent, J.L. Riechmann

Research output: Contribution to journalArticleAcademicpeer-review

346 Citations (Scopus)

Abstract

The MADS-domain transcription factor APETALA1 (AP1) is a key regulator of Arabidopsis flower development. To understand the molecular mechanisms underlying AP1 function, we identified its target genes during floral initiation using a combination of gene expression profiling and genome-wide binding studies. Many of its targets encode transcriptional regulators, including known floral repressors. The latter genes are down-regulated by AP1, suggesting that it initiates floral development by abrogating the inhibitory effects of these genes. Although AP1 acts predominantly as a transcriptional repressor during the earliest stages of flower development, at more advanced stages it also activates regulatory genes required for floral organ formation, indicating a dynamic mode of action. Our results further imply that AP1 orchestrates floral initiation by integrating growth, patterning, and hormonal pathways
Original languageEnglish
Pages (from-to)85-89
JournalScience
Volume328
Issue number5974
DOIs
Publication statusPublished - 2010

Keywords

  • flowering time genes
  • transcription factors
  • meristem identity
  • arabidopsis
  • expression
  • leafy
  • activation
  • induction
  • fruitfull
  • microrna

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