Orally administered Lactobacillus strains differentially affect the direction and efficacy of the immune response

C.B.M. Maassen; J.C.A.M. van Holten; F. Balk; M.J. Heijne den Bak-Glashouwer; R. Leer; J.D. Laman; W.J.A. Boersma; E. Claassen

Orally administered Lactobacillus strains differentially affect the direction and efficacy of the immune response

C.B.M. Maassen, J.C.A.M. van Holten, F. Balk, M.J. Heijne den Bak-Glashouwer, R. Leer, J.D. Laman, W.J.A. Boersma, E. Claassen

Research output: Contribution to journal › Article › Academic › peer-review

46 Citations (Scopus)

Abstract

In mice, strain dependent cytokine production profiles are induced after oral administration of Lactobacillus. Such a cytokine profile seems to determine the direction and efficacy of the humoral response. In SJL mice lactobacilli are able to enhance or inhibit the development of disease after induction of experimental autoimmune encephalomyelitis (EAE). Immuno- histochemical analysis of cytokine profiles showed that differential modulation is obtained dependent on the Lactobacillus strain applied. Serum antibody responses to i.p. immunisation with chicken gama globulin in BALB/c mice are also modulated by oral application of Lactobacillus. Lactobacilli are now being developed as safe live antigen carriers for application in vaccine technology, but also for the excretion of autoantigens in order to induce tolerance. The findings of this study imply that by proper strain selection the direction of the response can be influenced by the induction of a specific cytokine profile.

Original language	English
Pages (from-to)	S81-S83
Journal	Veterinary Quarterly
Volume	20
Issue number	SUPPL. 3
Publication status	Published - 1998

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@article{f10fe45c81c34ff7b8ea62f92e653bce,

title = "Orally administered Lactobacillus strains differentially affect the direction and efficacy of the immune response",

abstract = "In mice, strain dependent cytokine production profiles are induced after oral administration of Lactobacillus. Such a cytokine profile seems to determine the direction and efficacy of the humoral response. In SJL mice lactobacilli are able to enhance or inhibit the development of disease after induction of experimental autoimmune encephalomyelitis (EAE). Immuno- histochemical analysis of cytokine profiles showed that differential modulation is obtained dependent on the Lactobacillus strain applied. Serum antibody responses to i.p. immunisation with chicken gama globulin in BALB/c mice are also modulated by oral application of Lactobacillus. Lactobacilli are now being developed as safe live antigen carriers for application in vaccine technology, but also for the excretion of autoantigens in order to induce tolerance. The findings of this study imply that by proper strain selection the direction of the response can be influenced by the induction of a specific cytokine profile.",

author = "C.B.M. Maassen and {van Holten}, J.C.A.M. and F. Balk and {Heijne den Bak-Glashouwer}, M.J. and R. Leer and J.D. Laman and W.J.A. Boersma and E. Claassen",

year = "1998",

language = "English",

volume = "20",

pages = "S81--S83",

journal = "Veterinary Quarterly",

issn = "0165-2176",

publisher = "Taylor & Francis",

number = "SUPPL. 3",

}

Orally administered Lactobacillus strains differentially affect the direction and efficacy of the immune response. / Maassen, C.B.M.; van Holten, J.C.A.M.; Balk, F.; Heijne den Bak-Glashouwer, M.J.; Leer, R.; Laman, J.D.; Boersma, W.J.A.; Claassen, E.

In: Veterinary Quarterly, Vol. 20, No. SUPPL. 3, 1998, p. S81-S83.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Orally administered Lactobacillus strains differentially affect the direction and efficacy of the immune response

AU - Maassen, C.B.M.

AU - van Holten, J.C.A.M.

AU - Balk, F.

AU - Heijne den Bak-Glashouwer, M.J.

AU - Leer, R.

AU - Laman, J.D.

AU - Boersma, W.J.A.

AU - Claassen, E.

PY - 1998

Y1 - 1998

N2 - In mice, strain dependent cytokine production profiles are induced after oral administration of Lactobacillus. Such a cytokine profile seems to determine the direction and efficacy of the humoral response. In SJL mice lactobacilli are able to enhance or inhibit the development of disease after induction of experimental autoimmune encephalomyelitis (EAE). Immuno- histochemical analysis of cytokine profiles showed that differential modulation is obtained dependent on the Lactobacillus strain applied. Serum antibody responses to i.p. immunisation with chicken gama globulin in BALB/c mice are also modulated by oral application of Lactobacillus. Lactobacilli are now being developed as safe live antigen carriers for application in vaccine technology, but also for the excretion of autoantigens in order to induce tolerance. The findings of this study imply that by proper strain selection the direction of the response can be influenced by the induction of a specific cytokine profile.

AB - In mice, strain dependent cytokine production profiles are induced after oral administration of Lactobacillus. Such a cytokine profile seems to determine the direction and efficacy of the humoral response. In SJL mice lactobacilli are able to enhance or inhibit the development of disease after induction of experimental autoimmune encephalomyelitis (EAE). Immuno- histochemical analysis of cytokine profiles showed that differential modulation is obtained dependent on the Lactobacillus strain applied. Serum antibody responses to i.p. immunisation with chicken gama globulin in BALB/c mice are also modulated by oral application of Lactobacillus. Lactobacilli are now being developed as safe live antigen carriers for application in vaccine technology, but also for the excretion of autoantigens in order to induce tolerance. The findings of this study imply that by proper strain selection the direction of the response can be influenced by the induction of a specific cytokine profile.

M3 - Article

VL - 20

SP - S81-S83

JO - Veterinary Quarterly

JF - Veterinary Quarterly

SN - 0165-2176

IS - SUPPL. 3

ER -