Oral and transdermal estrogens both lower plasma total homocysteine in male-to-female transsexuals

E.J. Giltay, P. Verhoef, L.J.G. Gooren, J.M. Geleijnse, E.G. Schouten, C.D.A. Stehouwer

Research output: Contribution to journalArticleAcademicpeer-review

33 Citations (Scopus)

Abstract

Plasma total homocysteine (tHcy) levels are on average lower in women versus men, indicating an estrogenic effect. Oral estrogens (absorbed via the liver) may be hypothesized to have stronger effects on hepatic homocysteine metabolism than transdermal estrogens. We randomly assigned 30 male-to-female transsexuals (20–44 years old) to 4 months’ administration of oral ethinyl estradiol (n=15) or transdermal 17ß-estradiol (n=15), both with the antiandrogen cyproterone acetate (CA). Ten other male controls were treated with CA only. At baseline and after 2 and 4 months, plasma tHcy was analyzed in conjunction with plasma folate. Oral ethinyl estradiol and transdermal 17ß-estradiol similarly reduced plasma tHcy (geometric mean 10.6 µmol/l [95% CI 8.2–13.9] to 7.5 [6.5; 8.8], and 11.3 [8.1; 16.4] to 8.4 [6.5; 11.1]; P
Original languageEnglish
Pages (from-to)139-146
JournalAtherosclerosis
Volume168
DOIs
Publication statusPublished - 2003

Keywords

  • c-reactive protein
  • postmenopausal women
  • estradiol
  • metabolism
  • disease
  • trial
  • serum
  • men
  • 17-beta-estradiol
  • contraceptives

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