Optimizing Multivitamin Supplementation for Sleeve Gastrectomy Patients

Laura Heusschen*, Agnes A.M. Berendsen, Mellody I. Cooiman, Laura N. Deden, Eric J. Hazebroek, Edo O. Aarts

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

4 Citations (Scopus)


Purpose: Micronutrient deficiencies are frequently reported after sleeve gastrectomy (SG), and therefore lifelong daily multivitamin supplementation is highly recommended. Based on literature and the results of a previous randomized controlled trial, a specialized multivitamin supplement for SG patients was further optimized (WLS Optimum 2.0, FitForMe). The present study reports on its short-term effectiveness. Materials and Methods: An open-label study was performed in which 76 patients were included to receive WLS Optimum 2.0 for 12 months (Opt 2.0 group). This group was compared with a group of 75 patients that had received WLS Optimum 1.0 for 12 months during a previous study (Opt 1.0 group). Results: Intention-to-treat analysis (Opt 1.0, n = 69; Opt 2.0, n = 75) showed higher serum levels of vitamin B12, vitamin B6, and zinc, and a lower prevalence of deficiencies for vitamin B12 and phosphate in the Opt 2.0 group. MCV and serum folic acid levels were higher in the Opt 1.0 group. Over the 12-month study period, mean increase in serum levels of phosphate, vitamin B6, and zinc was higher in the Opt 2.0 group, and MCV and serum vitamin D levels increased more in the Opt 1.0 group. Conclusion: The present study showed that the use of a specialized multivitamin supplement for SG patients is effective at preventing deficiencies for most vitamins and minerals, specifically in compliant patients. However, a strict follow-up regime remains necessary to monitor nutritional status and to improve patient compliance.

Original languageEnglish
Pages (from-to)2520-2528
JournalObesity Surgery
Issue number6
Early online date23 Feb 2021
Publication statusPublished - 2021


  • Bariatric surgery
  • Deficiencies
  • Metabolic surgery
  • Micronutrients
  • Minerals
  • Morbid obesity
  • Sleeve gastrectomy (SG)
  • Supplementation
  • Vitamins


Dive into the research topics of 'Optimizing Multivitamin Supplementation for Sleeve Gastrectomy Patients'. Together they form a unique fingerprint.

Cite this