Optimal Allocation of Pandemic Influenza Vaccine Depends on Age, Risk and Timing

S.D. Mylius, T.H.J. Hagenaars, A.K. Lugner, J. Wallinga

    Research output: Contribution to journalArticleAcademicpeer-review

    58 Citations (Scopus)

    Abstract

    The limited production capacity for vaccines raises the question what the best strategy is for allocating the vaccine to mitigate an influenza pandemic. We developed an age-structured model for spread of an influenza pandemic and validated it against observations from the Asian flu pandemic. Two strategies were evaluated: vaccination can be implemented at the start of the influenza pandemic, or vaccination will be implemented near the peak of it. Our results suggest prioritizing individuals with a high-risk of complications if a vaccine becomes available during a pandemic. If available at the start, vaccinating school children might be considered since this results in slightly lower expected number of deaths.
    Original languageEnglish
    Pages (from-to)3742-3749
    JournalVaccine
    Volume26
    Issue number29-30
    DOIs
    Publication statusPublished - 2008

    Fingerprint

    Influenza Vaccines
    Pandemics
    pandemic
    influenza
    vaccines
    Human Influenza
    Vaccines
    Vaccination
    vaccination
    school children
    death

    Keywords

    • strategies
    • netherlands
    • spread
    • strain
    • impact

    Cite this

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    abstract = "The limited production capacity for vaccines raises the question what the best strategy is for allocating the vaccine to mitigate an influenza pandemic. We developed an age-structured model for spread of an influenza pandemic and validated it against observations from the Asian flu pandemic. Two strategies were evaluated: vaccination can be implemented at the start of the influenza pandemic, or vaccination will be implemented near the peak of it. Our results suggest prioritizing individuals with a high-risk of complications if a vaccine becomes available during a pandemic. If available at the start, vaccinating school children might be considered since this results in slightly lower expected number of deaths.",
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    Optimal Allocation of Pandemic Influenza Vaccine Depends on Age, Risk and Timing. / Mylius, S.D.; Hagenaars, T.H.J.; Lugner, A.K.; Wallinga, J.

    In: Vaccine, Vol. 26, No. 29-30, 2008, p. 3742-3749.

    Research output: Contribution to journalArticleAcademicpeer-review

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    AU - Wallinga, J.

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