Onzekere effecten van foliumzuur op andere aandoeningen dan neuraalbuisdefecten

P. Verhoef, M.B. Katan

Research output: Contribution to journalArticleAcademicpeer-review

4 Citations (Scopus)


Periconceptional supplemention with folic acid prevents neural-tube defects in infants. However, contrary to expectations, clinical trials found no beneficial effect of folic acid on the recurrence of cardiovascular disease. Trial evidence on folic acid and cognitive decline or dementia is scarce, though observational studies suggest that high folate intake may prevent these disorders. In contrast, animal studies suggest that high doses of folic acid enhance the growth of existing tumours. However, recent clinical trials failed to show significant effects of folic acid on cancer incidence and mortality
Original languageDutch
Pages (from-to)1439-1442
JournalNederlands Tijdschrift voor Geneeskunde
Issue number26
Publication statusPublished - 2006


  • folic acid
  • folic acid deficiency
  • food additives
  • food enrichment
  • disease prevention
  • health
  • vitamin b complex

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