One Health and Distribution of AMR related plasmids

S. Felle*, M.S.M. Brouwer, K.T. Veldman, J.M.J. Rebel

*Corresponding author for this work

Research output: Contribution to conferenceAbstract


Antimicrobial resistance (AMR) is a major threat to animal and human health. It is estimated that in 2019, 1.27 million deaths worldwide were associated with bacterial AMR. This number is set to rise, with one study estimating that by 2050, if no action is taken, AMR could kill ten million people per year. The overuse and misuse of antibiotics in the human, and animal sectors has led to an increased spread of AMR within these sectors and the environment. Therefore, a One Health approach to tackle AMR is important. Plasmids are DNA molecules that are distinct from the chromosome. They are easily transmitted between bacteria. Plasmids play a significant role in the spread of AMR. The main aim of my PhD is to study the genetics of fluoroquinolone and colistin resistance in the One Health continuum, focussing particularly on plasmid mediated resistance in E. coli. Fluoroquinolone and colistin are both classified as critically important antibiotics for human medicine by the World Health Organisation. In order to cover all sectors I will use bacterial samples from the AMR monitoring of animals, humans and food. I will perform whole genome sequencing (both short and long-read sequencing) and use bioinformatics to understand the distribution and epidemiology of plasmids carrying genes which cause resistance to fluoroquinolones and colistin.
Original languageEnglish
Publication statusPublished - 24 Oct 2023
EventADP Science Day 2023 - Landgoed Welderen, Elst, Netherlands
Duration: 24 Oct 202324 Oct 2023


OtherADP Science Day 2023


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