One-carbon metabolites, B-vitamins and associations with systemic inflammation and angiogenesis biomarkers among colorectal cancer patients: Results from the ColoCare Study

Rama Kiblawi, Andreana N. Holowatyj, Biljana Gigic, Stefanie Brezina, Anne J.M.R. Geijsen, Jennifer Ose, Tengda Lin, Sheetal Hardikar, Caroline Himbert, Christy A. Warby, Jürgen Böhm, Martijn J.L. Bours, Fränzel J.B. Van Duijnhoven, Tanja Gumpenberger, Dieuwertje E. Kok, Janna L. Koole, Eline H. Van Roekel, Petra Schrotz-King, Arve Ulvik, Andrea GsurNina Habermann, Matty P. Weijenberg, Per Magne Ueland, Martin Schneider, Alexis Ulrich, Cornelia M. Ulrich, Mary Playdon*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

B-vitamins involved in one-carbon metabolism have been implicated in the development of inflammation- A nd angiogenesis-related chronic diseases, such as colorectal cancer. Yet, the role of one-carbon metabolism in inflammation and angiogenesis among colorectal cancer patients remains unclear.The objective of this study was to investigate associations of components of one-carbon metabolism with inflammation and angiogenesis biomarkers among newly diagnosed colorectal cancer patients (n=238) in the prospective ColoCare Study, Heidelberg.We cross-sectionally analyzed associations between 12 B-vitamins and one-carbon metabolites and 10 inflammation and angiogenesis biomarkers from pre-surgery serum samples using multivariable linear regression models. We further explored associations among novel biomarkers in these pathways with Spearman partial correlation analyses. We hypothesized that pyridoxal-5'-phosphate (PLP) is inversely associated with inflammatory biomarkers.We observed that PLP was inversely associated with CRP (r=-0.33, plinear<0.0001), SAA (r=-0.23, plinear=0.003), IL-6 (r=-0.39, plinear <0.0001), IL-8 (r=-0.20, plinear=0.02) and TNFα (r=-0.12, plinear=0.045). Similar findings were observed for 5-methyl-tetrahydrofolate and CRP (r=-0.14), SAA (r=-0.14) and TNFα (r=-0.15) among colorectal cancer patients. Folate catabolite apABG was positively correlated with IL-6 (r= 0.27, plinear<0.0001) and pABG was positively correlated with IL-8 (r= 0.21, plinear<0.0001), indicating higher folate utilization during inflammation.Our data support the hypothesis of inverse associations between PLP and inflammatory biomarkers among colorectal cancer patients. A better understanding of the role and inter-relation of PLP and other one-carbon metabolites with inflammatory processes among colorectal carcinogenesis and prognosis could identify targets for future dietary guidance for colorectal cancer patients.

Original languageEnglish
Pages (from-to)1187-1200
JournalBritish Journal of Nutrition
Volume123
Issue number10
DOIs
Publication statusPublished - 28 May 2020

Keywords

  • B-vitamins
  • colorectal cancer
  • CRPangiogenesis
  • folate
  • folic acid
  • inflammation
  • One-carbon metabolism
  • Vitamin B

Fingerprint Dive into the research topics of 'One-carbon metabolites, B-vitamins and associations with systemic inflammation and angiogenesis biomarkers among colorectal cancer patients: Results from the ColoCare Study'. Together they form a unique fingerprint.

Cite this