One after the other: A novel Bluetongue virus strain related to Toggenburg virus detected in the Piedmont region (North-western Italy), extends the panel of novel atypical BTV strains

Maurilia Marcacci, Serena Sant, Iolanda Mangone, Maria Goria, Alessandro Dondo, Simona Zoppi, René G.P. van Gennip, Maria Cristina Radaelli, Cesare Cammà, Piet A. van Rijn, Giovanni Savini, Alessio Lorusso

Research output: Contribution to journalArticleAcademicpeer-review

17 Citations (Scopus)

Abstract

In this rapid communication, a novel atypical bluetongue virus (BTV) strain detected in goats in the Piedmont region (north-western Italy) is described. This strain, BTV-Z ITA2017, is most related in Seg-2/VP-2 (83.8% nt/82.7% aa) to strain TOV of BTV-25. Reactive antisera of goats positive by cELISA for BTV antibodies failed to neutralize a chimeric virus expressing the outermost protein of TOV. Infected animals displayed low levels of RNAemia and absence of clinical signs consistent with bluetongue infection, a scenario described in animals infected with atypical BTV strains.
Original languageEnglish
Pages (from-to)370-374
JournalTransboundary and Emerging Diseases
Volume65
Issue number2
Early online date2018
DOIs
Publication statusPublished - Apr 2018

Fingerprint

Toggenburg
Bluetongue virus
piedmont
Italy
Viruses
viruses
Goats
goats
Bluetongue
bluetongue
animal communication
antiserum
Immune Sera
animals
antibodies
Antibodies
Infection
infection
Proteins
proteins

Keywords

  • Arboviruses
  • Diagnostics
  • Emerging diseases
  • Virus

Cite this

Marcacci, Maurilia ; Sant, Serena ; Mangone, Iolanda ; Goria, Maria ; Dondo, Alessandro ; Zoppi, Simona ; van Gennip, René G.P. ; Radaelli, Maria Cristina ; Cammà, Cesare ; van Rijn, Piet A. ; Savini, Giovanni ; Lorusso, Alessio. / One after the other : A novel Bluetongue virus strain related to Toggenburg virus detected in the Piedmont region (North-western Italy), extends the panel of novel atypical BTV strains. In: Transboundary and Emerging Diseases. 2018 ; Vol. 65, No. 2. pp. 370-374.
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title = "One after the other: A novel Bluetongue virus strain related to Toggenburg virus detected in the Piedmont region (North-western Italy), extends the panel of novel atypical BTV strains",
abstract = "In this rapid communication, a novel atypical bluetongue virus (BTV) strain detected in goats in the Piedmont region (north-western Italy) is described. This strain, BTV-Z ITA2017, is most related in Seg-2/VP-2 (83.8{\%} nt/82.7{\%} aa) to strain TOV of BTV-25. Reactive antisera of goats positive by cELISA for BTV antibodies failed to neutralize a chimeric virus expressing the outermost protein of TOV. Infected animals displayed low levels of RNAemia and absence of clinical signs consistent with bluetongue infection, a scenario described in animals infected with atypical BTV strains.",
keywords = "Arboviruses, Diagnostics, Emerging diseases, Virus",
author = "Maurilia Marcacci and Serena Sant and Iolanda Mangone and Maria Goria and Alessandro Dondo and Simona Zoppi and {van Gennip}, {Ren{\'e} G.P.} and Radaelli, {Maria Cristina} and Cesare Camm{\`a} and {van Rijn}, {Piet A.} and Giovanni Savini and Alessio Lorusso",
year = "2018",
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One after the other : A novel Bluetongue virus strain related to Toggenburg virus detected in the Piedmont region (North-western Italy), extends the panel of novel atypical BTV strains. / Marcacci, Maurilia; Sant, Serena; Mangone, Iolanda; Goria, Maria; Dondo, Alessandro; Zoppi, Simona; van Gennip, René G.P.; Radaelli, Maria Cristina; Cammà, Cesare; van Rijn, Piet A.; Savini, Giovanni; Lorusso, Alessio.

In: Transboundary and Emerging Diseases, Vol. 65, No. 2, 04.2018, p. 370-374.

Research output: Contribution to journalArticleAcademicpeer-review

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T2 - A novel Bluetongue virus strain related to Toggenburg virus detected in the Piedmont region (North-western Italy), extends the panel of novel atypical BTV strains

AU - Marcacci, Maurilia

AU - Sant, Serena

AU - Mangone, Iolanda

AU - Goria, Maria

AU - Dondo, Alessandro

AU - Zoppi, Simona

AU - van Gennip, René G.P.

AU - Radaelli, Maria Cristina

AU - Cammà, Cesare

AU - van Rijn, Piet A.

AU - Savini, Giovanni

AU - Lorusso, Alessio

PY - 2018/4

Y1 - 2018/4

N2 - In this rapid communication, a novel atypical bluetongue virus (BTV) strain detected in goats in the Piedmont region (north-western Italy) is described. This strain, BTV-Z ITA2017, is most related in Seg-2/VP-2 (83.8% nt/82.7% aa) to strain TOV of BTV-25. Reactive antisera of goats positive by cELISA for BTV antibodies failed to neutralize a chimeric virus expressing the outermost protein of TOV. Infected animals displayed low levels of RNAemia and absence of clinical signs consistent with bluetongue infection, a scenario described in animals infected with atypical BTV strains.

AB - In this rapid communication, a novel atypical bluetongue virus (BTV) strain detected in goats in the Piedmont region (north-western Italy) is described. This strain, BTV-Z ITA2017, is most related in Seg-2/VP-2 (83.8% nt/82.7% aa) to strain TOV of BTV-25. Reactive antisera of goats positive by cELISA for BTV antibodies failed to neutralize a chimeric virus expressing the outermost protein of TOV. Infected animals displayed low levels of RNAemia and absence of clinical signs consistent with bluetongue infection, a scenario described in animals infected with atypical BTV strains.

KW - Arboviruses

KW - Diagnostics

KW - Emerging diseases

KW - Virus

U2 - 10.1111/tbed.12822

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