On the modulation of innate immunity by plant-parasitic cyst nematodes

W.J. Postma

Research output: Thesisinternal PhD, WU

Abstract

Plant-parasitic cyst nematodes are major agricultural pests worldwide. These obligate endoparasites invade the roots of host plants where they transform cells near the vascular cylinder into a permanent feeding site. Plants possess a multilayered innate immune system consisting of different types of extracellular and intracellular immune receptors. These enable detection of most invading nematodes and initiate immune responses that result in resistance. Many plant pathogens use effectors to overcome resistance. Here, modulation of plant innate immunity by plant-parasitic cyst nematodes was investigated. Extracellular immune receptor signaling and hormone-mediated signaling pathways were found to contain infection of susceptible Arabidopsis thalianawith Heterodera schachtii. A large family of effectors was identified in Globodera rostochiensis. One of these so-called SPRYSECs interacted with a novel CC-NB-LRR type resistance protein of a susceptible tomato without inducing resistance responses. Instead, the effector was found to suppress defense-related programmed cell death and resistance mediated by several CC-NB-LRR type resistance proteins. In addition, a secreted antimicrobial peptide was identified in G. rostochiensis. Plant-parasitic cyst nematodes thus most likely secrete effectors that protect against plant immune responses and secondary infections. The current evidence for the existence of immune modulating effectors is reviewed and directions for further research are given.

Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • Wageningen University
Supervisors/Advisors
  • Bakker, Jaap, Promotor
  • Smant, Geert, Co-promotor
  • Goverse, Aska, Co-promotor
Award date13 Jun 2013
Place of PublicationS.l.
Publisher
Print ISBNs9789461735560
Publication statusPublished - 2013

Fingerprint

parasitic plants
cyst nematodes
Globodera rostochiensis
immune response
Heterodera schachtii
endoparasites
antimicrobial peptides
biological resistance
blood vessels
plant pathogens
host plants
apoptosis
proteins
hormones
Arabidopsis
Nematoda
pests
tomatoes
innate immunity
cells

Keywords

  • plant parasitic nematodes
  • globodera rostochiensis
  • heterodera schachtii
  • plants
  • interactions
  • immunity
  • immune system
  • modulation
  • receptors
  • signal transduction
  • molecular plant pathology

Cite this

@phdthesis{cd379a70aa7a4376bbc69ae037f4b9a1,
title = "On the modulation of innate immunity by plant-parasitic cyst nematodes",
abstract = "Plant-parasitic cyst nematodes are major agricultural pests worldwide. These obligate endoparasites invade the roots of host plants where they transform cells near the vascular cylinder into a permanent feeding site. Plants possess a multilayered innate immune system consisting of different types of extracellular and intracellular immune receptors. These enable detection of most invading nematodes and initiate immune responses that result in resistance. Many plant pathogens use effectors to overcome resistance. Here, modulation of plant innate immunity by plant-parasitic cyst nematodes was investigated. Extracellular immune receptor signaling and hormone-mediated signaling pathways were found to contain infection of susceptible Arabidopsis thalianawith Heterodera schachtii. A large family of effectors was identified in Globodera rostochiensis. One of these so-called SPRYSECs interacted with a novel CC-NB-LRR type resistance protein of a susceptible tomato without inducing resistance responses. Instead, the effector was found to suppress defense-related programmed cell death and resistance mediated by several CC-NB-LRR type resistance proteins. In addition, a secreted antimicrobial peptide was identified in G. rostochiensis. Plant-parasitic cyst nematodes thus most likely secrete effectors that protect against plant immune responses and secondary infections. The current evidence for the existence of immune modulating effectors is reviewed and directions for further research are given.",
keywords = "plantenparasitaire nematoden, globodera rostochiensis, heterodera schachtii, planten, interacties, immuniteit, immuunsysteem, modulatie, receptoren, signaaltransductie, moleculaire plantenziektekunde, plant parasitic nematodes, globodera rostochiensis, heterodera schachtii, plants, interactions, immunity, immune system, modulation, receptors, signal transduction, molecular plant pathology",
author = "W.J. Postma",
note = "WU thesis 5480",
year = "2013",
language = "English",
isbn = "9789461735560",
publisher = "s.n.",
school = "Wageningen University",

}

Postma, WJ 2013, 'On the modulation of innate immunity by plant-parasitic cyst nematodes', Doctor of Philosophy, Wageningen University, S.l..

On the modulation of innate immunity by plant-parasitic cyst nematodes. / Postma, W.J.

S.l. : s.n., 2013. 154 p.

Research output: Thesisinternal PhD, WU

TY - THES

T1 - On the modulation of innate immunity by plant-parasitic cyst nematodes

AU - Postma, W.J.

N1 - WU thesis 5480

PY - 2013

Y1 - 2013

N2 - Plant-parasitic cyst nematodes are major agricultural pests worldwide. These obligate endoparasites invade the roots of host plants where they transform cells near the vascular cylinder into a permanent feeding site. Plants possess a multilayered innate immune system consisting of different types of extracellular and intracellular immune receptors. These enable detection of most invading nematodes and initiate immune responses that result in resistance. Many plant pathogens use effectors to overcome resistance. Here, modulation of plant innate immunity by plant-parasitic cyst nematodes was investigated. Extracellular immune receptor signaling and hormone-mediated signaling pathways were found to contain infection of susceptible Arabidopsis thalianawith Heterodera schachtii. A large family of effectors was identified in Globodera rostochiensis. One of these so-called SPRYSECs interacted with a novel CC-NB-LRR type resistance protein of a susceptible tomato without inducing resistance responses. Instead, the effector was found to suppress defense-related programmed cell death and resistance mediated by several CC-NB-LRR type resistance proteins. In addition, a secreted antimicrobial peptide was identified in G. rostochiensis. Plant-parasitic cyst nematodes thus most likely secrete effectors that protect against plant immune responses and secondary infections. The current evidence for the existence of immune modulating effectors is reviewed and directions for further research are given.

AB - Plant-parasitic cyst nematodes are major agricultural pests worldwide. These obligate endoparasites invade the roots of host plants where they transform cells near the vascular cylinder into a permanent feeding site. Plants possess a multilayered innate immune system consisting of different types of extracellular and intracellular immune receptors. These enable detection of most invading nematodes and initiate immune responses that result in resistance. Many plant pathogens use effectors to overcome resistance. Here, modulation of plant innate immunity by plant-parasitic cyst nematodes was investigated. Extracellular immune receptor signaling and hormone-mediated signaling pathways were found to contain infection of susceptible Arabidopsis thalianawith Heterodera schachtii. A large family of effectors was identified in Globodera rostochiensis. One of these so-called SPRYSECs interacted with a novel CC-NB-LRR type resistance protein of a susceptible tomato without inducing resistance responses. Instead, the effector was found to suppress defense-related programmed cell death and resistance mediated by several CC-NB-LRR type resistance proteins. In addition, a secreted antimicrobial peptide was identified in G. rostochiensis. Plant-parasitic cyst nematodes thus most likely secrete effectors that protect against plant immune responses and secondary infections. The current evidence for the existence of immune modulating effectors is reviewed and directions for further research are given.

KW - plantenparasitaire nematoden

KW - globodera rostochiensis

KW - heterodera schachtii

KW - planten

KW - interacties

KW - immuniteit

KW - immuunsysteem

KW - modulatie

KW - receptoren

KW - signaaltransductie

KW - moleculaire plantenziektekunde

KW - plant parasitic nematodes

KW - globodera rostochiensis

KW - heterodera schachtii

KW - plants

KW - interactions

KW - immunity

KW - immune system

KW - modulation

KW - receptors

KW - signal transduction

KW - molecular plant pathology

M3 - internal PhD, WU

SN - 9789461735560

PB - s.n.

CY - S.l.

ER -