Omega-3 alpha-linolenic fatty acid affects the level of telomere binding protein trf1 in porcine skeletal muscle

Magdalena Ogłuszka*, Marinus F.W. Te Pas, Ewa Poławska, Agata Nawrocka, Kamila Stepanow, Mariusz Pierzchała

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


Omega-3 fatty acids are health-promoting nutrients that contribute to the amelioration of age-related diseases. Recent studies have reported the role of these fatty acids in the aging process, explicitly impacting telomere biology. The shelterin protein complex, located at the extremities of chromosomes, ensures telomere protection and length regulation. Here, we analyzed the impact of dietary omega-3 alpha-linolenic fatty acid from linseed oil on skeletal muscle telomere biology using an animal model of female pigs. Fifteen animals were supplemented with linseed oil for nine weeks and an equal number of individuals were fed with a control diet. Linseed-oil-supplemented animals showed an increased level of alpha-linolenic acid in skeletal muscles compared to control animals. There was no difference between groups in the telomere length measured in leukocytes and muscles. However, muscles of the linseed-oil-supplemented pigs showed lower levels of the shelterin TRF1 protein compared to the control group. Our results suggest that omega-3 linolenic acid counteracts the elevation of TRF1 levels, which increase with age and due to the presence of reactive oxygen species in muscle. The observed effect may be due to attenuation of oxidative stress.

Original languageEnglish
Article number1090
Number of pages12
Issue number6
Publication statusPublished - 24 Jun 2020


  • Aging
  • Omega-3 fatty acid
  • Pigs
  • Shelterin
  • Skeletal muscle
  • Telomere
  • TRF1


Dive into the research topics of 'Omega-3 alpha-linolenic fatty acid affects the level of telomere binding protein trf1 in porcine skeletal muscle'. Together they form a unique fingerprint.

Cite this