Nutritional strategies for mucosal health: the interplay between microbes and mucin glycans

Clara Belzer*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

8 Citations (Scopus)

Abstract

Many aspects of the mechanisms underlying the symbiosis between humans and gut microbes remain unknown and encompass some of the most intriguing questions in microbiome research. An important factor in this symbiosis is the interplay between microbes and human-produced glycans in mucin and breast milk. In this Opinion paper, I propose a synergy between the structural diversity of human mucin glycans and the enzymatic repertoire of the gut microbiome. The contribution of microbes to mucosal health is discussed, and the role of breast milk glycans in mucosal colonization by microbes is explained. The use of prebiotic mucin glycans in general, and specialized infant and medical nutrition in particular, should be considered as the field of interest to modulate the microbiota and improve mucosal health.

Original languageEnglish
Pages (from-to)13-21
JournalTrends in Microbiology
Volume30
Issue number1
Early online date30 Jun 2021
DOIs
Publication statusPublished - 2022

Keywords

  • microbiome
  • mucin
  • mucosal layer
  • prebiotic glycans

Fingerprint

Dive into the research topics of 'Nutritional strategies for mucosal health: the interplay between microbes and mucin glycans'. Together they form a unique fingerprint.

Cite this