Nutritional Genetics: The Case of Alcohol and the MTHFR C677T Polymorphism in relation to homocysteine in a Black South African Population

C. Nienaber-Rousseau, P.T. Pisa, C.S. Venster, S.M. Ellis, A. Kruger, S. Moss, A. Boonstra, G.W. Towers

Research output: Contribution to journalArticleAcademicpeer-review

8 Citations (Scopus)

Abstract

Background/Aims: It is unknown whether the effect of alcohol consumption on homocysteine (Hcy) is modulated by the methylenetetrahydrofolate reductase (MTHFR) C677T. We explored this hypothesized effect by analyzing cross-sectional data of 1,827 black South Africans. Methods: Total Hcy concentrations were determined by fluorescence polarization immunoassay and the genotype through polymerase chain reaction-based RFLP analysis. Results: Subjects harboring the 677 TT genotype had the highest Hcy. Among subjects harboring the 677 CC genotype, men had higher Hcy (p = 0.04). Age and gamma-glutamyltransferase (GGT) correlated best (r = 0.26 and r = 0.27; p <0.05), while the percentage carbohydrate-deficient transferrin and the B vitamins correlated weakly (r <0.1; p <0.05) with Hcy. Hcy was positively associated with the reported alcohol intake (p = 0.01). There was no interaction between alcohol consumption and the MTHFR 677 CC or CT genotypes (p > 0.05) for Hcy concentrations; however, an interaction was determined for GGT and the MTHFR genotype (p = 0.02). Age, GGT, gender, MTHFR and vitamin B6 explained 16.8% of the variation in Hcy (p <0.01). Conclusion: The determined interactions might result in differences in the risk conveyed through Hcy with regard to disease development in those with unfavorable GGT concentrations.
Original languageEnglish
Pages (from-to)61-72
Number of pages11
JournalJournal of Nutrigenetics and Nutrigenomics
Volume6
Issue number2
DOIs
Publication statusPublished - 2013

Keywords

  • coronary-heart-disease
  • cardiovascular risk-factors
  • plasma total homocysteine
  • methylenetetrahydrofolate reductase
  • consumption
  • hyperhomocysteinemia
  • folate
  • determinants
  • metaanalysis
  • frequency

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