Nutrikinetics: concept, technololgies applications and perspectives

J.P.M. van Duynhoven, E.J.J. van Velzen, J.A. Westerhuis, M. Foltz, D.M. Jacobs, A.K. Smilde

Research output: Contribution to journalArticleAcademicpeer-review

19 Citations (Scopus)

Abstract

Exposure studies are the first step in predicting bioactivity of phytochemicals in humans. Due to the interaction between phytochemicals, their food matrix, the gut microbiome and the host, the resulting exogenous metabolites in systemic circulation vary largely between individuals. Nutrikinetics is an extension of the classical pharmacokinetic concept with explicit model adaptations. The concept relies on integrated deployment of metabolic profiling, multi-level data analysis and population-based single compartment modelling. Nutrikinetics is expected to make critical contributions in understanding how phenotypes and the food matrix modulate bioactivity of dietary phytochemicals, in particular when gut microbial bioconversions are involved.
Original languageEnglish
Pages (from-to)4-13
JournalTrends in Food Science and Technology
Volume26
Issue number1
DOIs
Publication statusPublished - 2012

Fingerprint

Phytochemicals
phytopharmaceuticals
food matrix
Food
metabolomics
biotransformation
intestinal microorganisms
pharmacokinetics
data analysis
digestive system
Pharmacokinetics
metabolites
Phenotype
phenotype
Population

Keywords

  • human metabolic phenotypes
  • nutrition research
  • systems biology
  • intestinal microbiota
  • phenolic-acids
  • dietary phytochemicals
  • tea polyphenols
  • food components
  • gut microbiome
  • black tea

Cite this

van Duynhoven, J.P.M. ; van Velzen, E.J.J. ; Westerhuis, J.A. ; Foltz, M. ; Jacobs, D.M. ; Smilde, A.K. / Nutrikinetics: concept, technololgies applications and perspectives. In: Trends in Food Science and Technology. 2012 ; Vol. 26, No. 1. pp. 4-13.
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Nutrikinetics: concept, technololgies applications and perspectives. / van Duynhoven, J.P.M.; van Velzen, E.J.J.; Westerhuis, J.A.; Foltz, M.; Jacobs, D.M.; Smilde, A.K.

In: Trends in Food Science and Technology, Vol. 26, No. 1, 2012, p. 4-13.

Research output: Contribution to journalArticleAcademicpeer-review

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AU - Foltz, M.

AU - Jacobs, D.M.

AU - Smilde, A.K.

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KW - nutrition research

KW - systems biology

KW - intestinal microbiota

KW - phenolic-acids

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KW - tea polyphenols

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