Nutrikinetic assessment of polyphenol exposure

John van Duynhoven; Ewoud J.J. Van Velzen; Doris Maria Jacobs

doi:10.1016/j.cofs.2017.09.004

Nutrikinetic assessment of polyphenol exposure

John van Duynhoven^*, Ewoud J.J. Van Velzen, Doris Maria Jacobs

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

6 Citations (Scopus)

Abstract

The key to link intake of polyphenols to health benefits is the quantitative and kinetic assessment of their metabolites in circulation. Current analytical approaches have only provided limited quantitative coverage of the internal polyphenol metabolome, this in particular pertains to conjugated microbial catabolites. Current modelling approaches to describe the kinetic appearance of polyphenol metabolites into circulation mostly neglect the multi-compartment nature of polyphenol metabolism in the body. Furthermore, inter-individual variation is mostly neglected in current modelling approaches. These gaps hamper clear definition of the modulating effects of metabotypes and food matrix on the internal polyphenol metabolome.

Original language	English
Pages (from-to)	88-95
Journal	Current Opinion in Food Science
Volume	16
DOIs	https://doi.org/10.1016/j.cofs.2017.09.004
Publication status	Published - 2017

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10.1016/j.cofs.2017.09.004

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title = "Nutrikinetic assessment of polyphenol exposure",

abstract = "The key to link intake of polyphenols to health benefits is the quantitative and kinetic assessment of their metabolites in circulation. Current analytical approaches have only provided limited quantitative coverage of the internal polyphenol metabolome, this in particular pertains to conjugated microbial catabolites. Current modelling approaches to describe the kinetic appearance of polyphenol metabolites into circulation mostly neglect the multi-compartment nature of polyphenol metabolism in the body. Furthermore, inter-individual variation is mostly neglected in current modelling approaches. These gaps hamper clear definition of the modulating effects of metabotypes and food matrix on the internal polyphenol metabolome.",

author = "{van Duynhoven}, John and {Van Velzen}, {Ewoud J.J.} and Jacobs, {Doris Maria}",

year = "2017",

doi = "10.1016/j.cofs.2017.09.004",

language = "English",

volume = "16",

pages = "88--95",

journal = "Current Opinion in Food Science",

issn = "2214-7993",

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T1 - Nutrikinetic assessment of polyphenol exposure

AU - van Duynhoven, John

AU - Van Velzen, Ewoud J.J.

AU - Jacobs, Doris Maria

PY - 2017

Y1 - 2017

N2 - The key to link intake of polyphenols to health benefits is the quantitative and kinetic assessment of their metabolites in circulation. Current analytical approaches have only provided limited quantitative coverage of the internal polyphenol metabolome, this in particular pertains to conjugated microbial catabolites. Current modelling approaches to describe the kinetic appearance of polyphenol metabolites into circulation mostly neglect the multi-compartment nature of polyphenol metabolism in the body. Furthermore, inter-individual variation is mostly neglected in current modelling approaches. These gaps hamper clear definition of the modulating effects of metabotypes and food matrix on the internal polyphenol metabolome.

AB - The key to link intake of polyphenols to health benefits is the quantitative and kinetic assessment of their metabolites in circulation. Current analytical approaches have only provided limited quantitative coverage of the internal polyphenol metabolome, this in particular pertains to conjugated microbial catabolites. Current modelling approaches to describe the kinetic appearance of polyphenol metabolites into circulation mostly neglect the multi-compartment nature of polyphenol metabolism in the body. Furthermore, inter-individual variation is mostly neglected in current modelling approaches. These gaps hamper clear definition of the modulating effects of metabotypes and food matrix on the internal polyphenol metabolome.

U2 - 10.1016/j.cofs.2017.09.004

DO - 10.1016/j.cofs.2017.09.004

M3 - Article

AN - SCOPUS:85030107870

SN - 2214-7993

VL - 16

SP - 88

EP - 95

JO - Current Opinion in Food Science

JF - Current Opinion in Food Science

ER -

Nutrikinetic assessment of polyphenol exposure

Abstract

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