Novel solutions for a model of wound healing angiogenesis

K. Harley*, P. Van Heijster, R. Marangell, G.J. Pettet, M. Wechselberger

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

7 Citations (Scopus)

Abstract

We prove the existence of novel, shock-fronted travelling wave solutions to a model of wound healing angiogenesis studied in Pettet et al (2000 IMA J. Math. App. Med. 17 395-413) assuming two conjectures hold. In the previous work, the authors showed that for certain parameter values, a heteroclinic orbit in the phase plane representing a smooth travelling wave solution exists. However, upon varying one of the parameters, the heteroclinic orbit was destroyed, or rather cut-off, by a wall of singularities in the phase plane. As a result, they concluded that under this parameter regime no travelling wave solutions existed. Using techniques from geometric singular perturbation theory and canard theory, we show that a travelling wave solution actually still exists for this parameter regime. We construct a heteroclinic orbit passing through the wall of singularities via a folded saddle canard point onto a repelling slow manifold. The orbit leaves this manifold via the fast dynamics and lands on the attracting slow manifold, finally connecting to its end state. This new travelling wave is no longer smooth but exhibits a sharp front or shock. Finally, we identify regions in parameter space where we expect that similar solutions exist. Moreover, we discuss the possibility of more exotic solutions.

Original languageEnglish
Article number2975
Pages (from-to)2975-3003
Number of pages29
JournalNonlinearity
Volume27
Issue number12
DOIs
Publication statusPublished - Dec 2014
Externally publishedYes

Keywords

  • advection-reaction-diffusion systems
  • canards
  • singularly perturbed systems
  • travelling wave solutions
  • wound healing angiogenesis

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