Novel Multilayer IR-786-loaded Nanocarriers for Intracellular Delivering: Characterization, Imaging, and Internalization in Human Cancer Cell Lines

U. Bazylinska, J. Saczko, K. Zielinska, K.A. Wilk

    Research output: Contribution to journalArticleAcademicpeer-review

    20 Citations (Scopus)

    Abstract

    We aimed to fabricate new oil-core polyelectrolyte-shell nanocapsules loaded with IR-786 cyanine, a third generation photosensitizer, and to evaluate their biocompatibility upon different human cancer cell lines, i.e., breast (MCF-7/WT), skin melanoma (MEWO), and lung (A549). The nanocarriers were fabricated via direct layer-by-layer adsorption of polyanionic poly(L-glutamic acid) sodium salt (PGA) and polycationic poly(L-lysine) (PLL) on a positively charged nanoemulsion template stabilized by N,N-bis[3,3'-(trimethylammonio)propyl]-dodecaneamide dimethylsulfate, C-12(TAPAMS)(2). All studied nanocapsules demonstrated good capacity for IR-786 encapsulation, cellular internalization, and low cytotoxicity.
    Original languageEnglish
    Pages (from-to)1354-1356
    JournalChemistry Letters
    Volume41
    Issue number10
    DOIs
    Publication statusPublished - 2012

    Keywords

    • nanocapsules

    Fingerprint

    Dive into the research topics of 'Novel Multilayer IR-786-loaded Nanocarriers for Intracellular Delivering: Characterization, Imaging, and Internalization in Human Cancer Cell Lines'. Together they form a unique fingerprint.

    Cite this