Novel carbapenemases FLC-1 and IMI-2 encoded by an enterobacter cloacae complex isolated from food products

Michael S.M. Brouwer; Kamaleddin H.M.E. Tehrani; Michel Rapallini; Yvon Geurts; Arie Kant; Frank Harders; Vida Mashayekhi; Nathaniel I. Martin; Alex Bossers; Dik J. Mevius; Ben Wit; Kees T. Veldman

doi:10.1128/AAC.02338-18

Novel carbapenemases FLC-1 and IMI-2 encoded by an enterobacter cloacae complex isolated from food products

Michael S.M. Brouwer^*
, Kamaleddin H.M.E. Tehrani
, Michel Rapallini
, Yvon Geurts
, Arie Kant
, Frank Harders
, Vida Mashayekhi
, Nathaniel I. Martin
, Alex Bossers
, Dik J. Mevius
, Ben Wit
, Kees T. Veldman

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

26 Citations (Scopus)

Abstract

Food for human consumption is screened widely for the presence of antibiotic-resistant bacteria to assess the potential for transfer of resistant bacteria to the general population. Here, we describe an Enterobacter cloacae complex isolated from imported seafood that encodes two carbapenemases on two distinct plasmids. Both enzymes belong to Ambler class A -lactamases, the previously described IMI-2 and a novel family designated FLC-1. The hydrolytic activity of the novel enzyme against aminopenicillins, cephalosporins, and carbapenems was determined.

Original language	English
Article number	e02338-18
Journal	Antimicrobial Agents and Chemotherapy
Volume	63
Issue number	6
DOIs	https://doi.org/10.1128/AAC.02338-18
Publication status	Published - 1 Jun 2019

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Antimicrobial resistance
Carbapenemase
Enterobacter
Plasmid

Access to Document

10.1128/AAC.02338-18Licence: CC BY

Enterobacter hormaechei strain:E3442 Genome sequencing
Brouwer, M. S. M. (Creator), Tehrani, K. H. M. E. (Creator), Rapallini, M. (Creator), Geurts, Y. (Creator), Kant, A. (Creator), Harders, F. (Creator), Mashayekhi, V. (Creator), Martin, N. I. (Creator), Bossers, A. (Creator), Mevius, D. J. (Creator), Wit, B. (Creator) & Veldman, K. T. (Creator), Wageningen University & Research, 10 Nov 2018
https://www.ncbi.nlm.nih.gov/bioproject/503409
Dataset

Surveillance van landbouwhuisdieren op CPE (BO-43-209-012, BO-43-111-009, BO-43-013.03-002, BO-20-016-006)
Veldman, K. (Project Leader)
1/01/14 → 31/12/29
Project: LVVN project

Cite this

Brouwer, M. S. M., Tehrani, K. H. M. E., Rapallini, M., Geurts, Y., Kant, A., Harders, F., Mashayekhi, V., Martin, N. I., Bossers, A., Mevius, D. J., Wit, B., & Veldman, K. T. (2019). Novel carbapenemases FLC-1 and IMI-2 encoded by an enterobacter cloacae complex isolated from food products. Antimicrobial Agents and Chemotherapy, 63(6), Article e02338-18. https://doi.org/10.1128/AAC.02338-18

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title = "Novel carbapenemases FLC-1 and IMI-2 encoded by an enterobacter cloacae complex isolated from food products",

abstract = "Food for human consumption is screened widely for the presence of antibiotic-resistant bacteria to assess the potential for transfer of resistant bacteria to the general population. Here, we describe an Enterobacter cloacae complex isolated from imported seafood that encodes two carbapenemases on two distinct plasmids. Both enzymes belong to Ambler class A -lactamases, the previously described IMI-2 and a novel family designated FLC-1. The hydrolytic activity of the novel enzyme against aminopenicillins, cephalosporins, and carbapenems was determined.",

keywords = "Antimicrobial resistance, Carbapenemase, Enterobacter, Plasmid",

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AU - Brouwer, Michael S.M.

AU - Tehrani, Kamaleddin H.M.E.

AU - Rapallini, Michel

AU - Geurts, Yvon

AU - Kant, Arie

AU - Harders, Frank

AU - Mashayekhi, Vida

AU - Martin, Nathaniel I.

AU - Bossers, Alex

AU - Mevius, Dik J.

AU - Wit, Ben

AU - Veldman, Kees T.

PY - 2019/6/1

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AB - Food for human consumption is screened widely for the presence of antibiotic-resistant bacteria to assess the potential for transfer of resistant bacteria to the general population. Here, we describe an Enterobacter cloacae complex isolated from imported seafood that encodes two carbapenemases on two distinct plasmids. Both enzymes belong to Ambler class A -lactamases, the previously described IMI-2 and a novel family designated FLC-1. The hydrolytic activity of the novel enzyme against aminopenicillins, cephalosporins, and carbapenems was determined.

KW - Antimicrobial resistance

KW - Carbapenemase

KW - Enterobacter

KW - Plasmid

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DO - 10.1128/AAC.02338-18

M3 - Article

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AN - SCOPUS:85066451071

SN - 0066-4804

VL - 63

JO - Antimicrobial Agents and Chemotherapy

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IS - 6

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ER -

Novel carbapenemases FLC-1 and IMI-2 encoded by an enterobacter cloacae complex isolated from food products

Abstract

UN SDGs

Keywords

Access to Document

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Datasets

Enterobacter hormaechei strain:E3442 Genome sequencing

Projects

Surveillance van landbouwhuisdieren op CPE (BO-43-209-012, BO-43-111-009, BO-43-013.03-002, BO-20-016-006)

Cite this