Novel carbapenemases FLC-1 and IMI-2 encoded by an enterobacter cloacae complex isolated from food products

Michael S.M. Brouwer, Kamaleddin H.M.E. Tehrani, Michel Rapallini, Yvon Geurts, Arie Kant, Frank Harders, Vida Mashayekhi, Nathaniel I. Martin, Alex Bossers, Dik J. Mevius, Ben Wit, Kees T. Veldman

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Food for human consumption is screened widely for the presence of antibiotic-resistant bacteria to assess the potential for transfer of resistant bacteria to the general population. Here, we describe an Enterobacter cloacae complex isolated from imported seafood that encodes two carbapenemases on two distinct plasmids. Both enzymes belong to Ambler class A -lactamases, the previously described IMI-2 and a novel family designated FLC-1. The hydrolytic activity of the novel enzyme against aminopenicillins, cephalosporins, and carbapenems was determined.

LanguageEnglish
Article numbere02338-18
JournalAntimicrobial Agents and Chemotherapy
Volume63
Issue number6
DOIs
Publication statusPublished - 1 Jun 2019

Fingerprint

Enterobacter cloacae
Bacteria
Food
Seafood
Carbapenems
Enzymes
Cephalosporins
Plasmids
Anti-Bacterial Agents
Population

Keywords

  • Antimicrobial resistance
  • Carbapenemase
  • Enterobacter
  • Plasmid

Cite this

@article{789f13e78bd849febb7321761b893c20,
title = "Novel carbapenemases FLC-1 and IMI-2 encoded by an enterobacter cloacae complex isolated from food products",
abstract = "Food for human consumption is screened widely for the presence of antibiotic-resistant bacteria to assess the potential for transfer of resistant bacteria to the general population. Here, we describe an Enterobacter cloacae complex isolated from imported seafood that encodes two carbapenemases on two distinct plasmids. Both enzymes belong to Ambler class A -lactamases, the previously described IMI-2 and a novel family designated FLC-1. The hydrolytic activity of the novel enzyme against aminopenicillins, cephalosporins, and carbapenems was determined.",
keywords = "Antimicrobial resistance, Carbapenemase, Enterobacter, Plasmid",
author = "Brouwer, {Michael S.M.} and Tehrani, {Kamaleddin H.M.E.} and Michel Rapallini and Yvon Geurts and Arie Kant and Frank Harders and Vida Mashayekhi and Martin, {Nathaniel I.} and Alex Bossers and Mevius, {Dik J.} and Ben Wit and Veldman, {Kees T.}",
year = "2019",
month = "6",
day = "1",
doi = "10.1128/AAC.02338-18",
language = "English",
volume = "63",
journal = "Antimicrobial Agents and Chemotherapy",
issn = "0066-4804",
publisher = "American Society for Microbiology",
number = "6",

}

Novel carbapenemases FLC-1 and IMI-2 encoded by an enterobacter cloacae complex isolated from food products. / Brouwer, Michael S.M.; Tehrani, Kamaleddin H.M.E.; Rapallini, Michel; Geurts, Yvon; Kant, Arie; Harders, Frank; Mashayekhi, Vida; Martin, Nathaniel I.; Bossers, Alex; Mevius, Dik J.; Wit, Ben; Veldman, Kees T.

In: Antimicrobial Agents and Chemotherapy, Vol. 63, No. 6, e02338-18, 01.06.2019.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Novel carbapenemases FLC-1 and IMI-2 encoded by an enterobacter cloacae complex isolated from food products

AU - Brouwer, Michael S.M.

AU - Tehrani, Kamaleddin H.M.E.

AU - Rapallini, Michel

AU - Geurts, Yvon

AU - Kant, Arie

AU - Harders, Frank

AU - Mashayekhi, Vida

AU - Martin, Nathaniel I.

AU - Bossers, Alex

AU - Mevius, Dik J.

AU - Wit, Ben

AU - Veldman, Kees T.

PY - 2019/6/1

Y1 - 2019/6/1

N2 - Food for human consumption is screened widely for the presence of antibiotic-resistant bacteria to assess the potential for transfer of resistant bacteria to the general population. Here, we describe an Enterobacter cloacae complex isolated from imported seafood that encodes two carbapenemases on two distinct plasmids. Both enzymes belong to Ambler class A -lactamases, the previously described IMI-2 and a novel family designated FLC-1. The hydrolytic activity of the novel enzyme against aminopenicillins, cephalosporins, and carbapenems was determined.

AB - Food for human consumption is screened widely for the presence of antibiotic-resistant bacteria to assess the potential for transfer of resistant bacteria to the general population. Here, we describe an Enterobacter cloacae complex isolated from imported seafood that encodes two carbapenemases on two distinct plasmids. Both enzymes belong to Ambler class A -lactamases, the previously described IMI-2 and a novel family designated FLC-1. The hydrolytic activity of the novel enzyme against aminopenicillins, cephalosporins, and carbapenems was determined.

KW - Antimicrobial resistance

KW - Carbapenemase

KW - Enterobacter

KW - Plasmid

U2 - 10.1128/AAC.02338-18

DO - 10.1128/AAC.02338-18

M3 - Article

VL - 63

JO - Antimicrobial Agents and Chemotherapy

T2 - Antimicrobial Agents and Chemotherapy

JF - Antimicrobial Agents and Chemotherapy

SN - 0066-4804

IS - 6

M1 - e02338-18

ER -