Novel carbapenemases FLC-1 and IMI-2 encoded by an enterobacter cloacae complex isolated from food products

Michael S.M. Brouwer*, Kamaleddin H.M.E. Tehrani, Michel Rapallini, Yvon Geurts, Arie Kant, Frank Harders, Vida Mashayekhi, Nathaniel I. Martin, Alex Bossers, Dik J. Mevius, Ben Wit, Kees T. Veldman

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

5 Citations (Scopus)

Abstract

Food for human consumption is screened widely for the presence of antibiotic-resistant bacteria to assess the potential for transfer of resistant bacteria to the general population. Here, we describe an Enterobacter cloacae complex isolated from imported seafood that encodes two carbapenemases on two distinct plasmids. Both enzymes belong to Ambler class A -lactamases, the previously described IMI-2 and a novel family designated FLC-1. The hydrolytic activity of the novel enzyme against aminopenicillins, cephalosporins, and carbapenems was determined.

Original languageEnglish
Article numbere02338-18
JournalAntimicrobial Agents and Chemotherapy
Volume63
Issue number6
DOIs
Publication statusPublished - 1 Jun 2019

Keywords

  • Antimicrobial resistance
  • Carbapenemase
  • Enterobacter
  • Plasmid

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