Not so hot: Optimal housing temperatures for mice to mimic the thermal environment of human

J. Speakman, J. Keijer

Research output: Contribution to journalArticleAcademicpeer-review

104 Citations (Scopus)

Abstract

It has been argued that mice should be housed at 30 °C to best mimic the thermal conditions experienced by humans, and that the current practice of housing mice at 20–22 °C impairs the suitability of mice as a model for human physiology and disease. In the current paper we challenge this notion. First, we show that humans routinely occupy environments about 3 °C below their lower critical temperature (Tlc), which when lightly clothed is about 23 °C. Second, we review the data for the Tlc of mice. Mouse Tlc is dependent on body weight and about 26–28 °C for adult mice weighing >25 g. The equivalent temperature to that normally experienced by humans for most single housed adult mice is therefore 23–25 °C. Group housing or providing the mice with bedding and nesting material might lower this to about 20–22 °C, close to current standard practice.
Original languageEnglish
Pages (from-to)5-9
JournalMolecular Metabolism
Volume2
Issue number1
DOIs
Publication statusPublished - 2013

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