No differences in muscle protein synthesis rates following ingestion of wheat protein, milk protein, and their protein blend in healthy, young males

Plant-derived proteins have been suggested to have less anabolic properties when compared with animal-derived proteins. Whether blends of plant-and animal-derived proteins can compensate for their lesser anabolic potential has not been assessed. This study compares post-prandial muscle protein synthesis rates following the ingestion of milk protein with wheat protein or a blend of wheat plus milk protein in healthy, young males. In a randomized, double blind, parallel-group design, 36 males (23±3 y) received a primed continuous L-[ring-13C6]-phenylalanine infusion after which they ingested 30 g milk protein (MILK), 30 g wheat protein (WHEAT), or a 30 g blend combining 15 g wheat plus 15 g milk protein (WHEAT+MILK). Blood and muscle biopsies were collected frequently for 5 hours to assess post-prandial plasma amino acid profiles and subsequent myofibrillar protein synthesis rates. Ingestion of protein increased myofibrillar protein synthesis rates in all treatments (P<0.001). Post-prandial myofibrillar protein synthesis rates did not differ between MILK vs WHEAT (0.053±0.013 vs 0.056±0.012™h-1, respectively; t-test P=0.56) or between MILK vs WHEAT+MILK (0.053±0.013 vs 0.059±0.025™h-1, respectively; t-test P=0.46). In conclusion, ingestion of 30 g milk protein, 30 g wheat protein, or a blend of 15 g wheat plus 15 g milk protein increases muscle protein synthesis rates in young males. Furthermore, muscle protein synthesis rates following the ingestion of 30 g milk protein do not differ from rates observed after ingesting 30 g wheat protein or a blend with 15 g milk plus 15 g wheat protein in healthy, young males.