No association of CTLA-4 polymorphisms with susceptibility to Behcet disease

L. Du, P. Yang, S. Hou, H. Zhou, A. Kijlstra

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12 Citations (Scopus)


Background: Cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) is a key negative regulator of T lymphocytes and has been shown to be associated with a number of autoimmune diseases. The present study was performed to assess the association between CTLA-4 polymorphisms and Behcet disease (BD) in Chinese patients. Methods: Two hundred and twenty-eight BD patients and 207 controls were analysed for four single nucleotide polymorphisms (SNPs) (21661A/G, 2318C/T, + 49G/A and CT60G/A) in the CTLA-4 gene by PCR-restriction fragment length polymorphism (RFLP) analysis. The association between SNP +49A/G and BD in Chinese population as well as other ethnic groups was analysed by meta-analysis. Results: No association could be detected between CTLA-4 SNPs or haplotypes and BD. Also, no association was observed between CTLA-4 polymorphisms and BD subgroups, stratified by clinical features. A meta-analysis showed that there was no heterogeneity between studies (p = 0.60, I-2 = 0%) and that CTLA-4 SNP + 49 was not associated with BD (overall effect: Z = 0.26, p = 0.79). Conclusion: This study and a meta-analysis failed to demonstrate any association between the tested CTLA-4 polymorphisms and BD
Original languageEnglish
Pages (from-to)1378-1381
JournalBritish Journal of Ophthalmology
Issue number10
Publication statusPublished - 2009


  • systemic-lupus-erythematosus
  • autoimmune-disease
  • gene polymorphisms
  • turkish patients
  • promoter
  • expression
  • chinese


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