TY - JOUR
T1 - Nitrofuran antibiotic residues in pork The FoodBRAND retail survey
AU - O'Keeffe, M.
AU - Conneely, A.
AU - Cooper, K.M.
AU - Kennedy, D.G.
AU - Kovacsics, L.
AU - Fodor, A.
AU - Mulder, P.P.J.
AU - van Rhijn, J.A.
AU - Trigueros, G.
PY - 2004
Y1 - 2004
N2 - Use of nitrofuran drugs in food-producing animals has been prohibited within the EU because they may represent a public health risk. Monitoring compliance with the ban has focused on the detection of protein-bound nitrofuran metabolites which, in contrast to the parent compounds, are stable and persist in animal tissues. As part of the "FoodBRAND" project, an extensive survey of pork was undertaken across 15 European countries. Samples (n = 1500) purchased at retail outlets were analysed for the nitrofuran metabolites AOZ, AMOZ, AHD and SEM using LC-MS/MS determination of nitrobenzaldehyde derivatives. Limits of quantification for the method were 0.1 g/kg (AOZ, AMOZ), 0.2 g/kg (SEM) and 0.5 g/kg (AHD). Of the 1500 samples tested, measurable residues of nitrofuran metabolites were confirmed in 12 samples (0.8% incidence overall) of which 10 samples were purchased in Portugal (AOZ, 0.3 g/kg; AMOZ, 0.2¿0.6 g/kg) and one sample each in Italy (AMOZ, 1.0 g/kg) and Greece (AOZ, 3.0 g/kg)
AB - Use of nitrofuran drugs in food-producing animals has been prohibited within the EU because they may represent a public health risk. Monitoring compliance with the ban has focused on the detection of protein-bound nitrofuran metabolites which, in contrast to the parent compounds, are stable and persist in animal tissues. As part of the "FoodBRAND" project, an extensive survey of pork was undertaken across 15 European countries. Samples (n = 1500) purchased at retail outlets were analysed for the nitrofuran metabolites AOZ, AMOZ, AHD and SEM using LC-MS/MS determination of nitrobenzaldehyde derivatives. Limits of quantification for the method were 0.1 g/kg (AOZ, AMOZ), 0.2 g/kg (SEM) and 0.5 g/kg (AHD). Of the 1500 samples tested, measurable residues of nitrofuran metabolites were confirmed in 12 samples (0.8% incidence overall) of which 10 samples were purchased in Portugal (AOZ, 0.3 g/kg; AMOZ, 0.2¿0.6 g/kg) and one sample each in Italy (AMOZ, 1.0 g/kg) and Greece (AOZ, 3.0 g/kg)
KW - chromatography-mass-spectrometry
KW - liquid-chromatography
KW - furazolidone
KW - tissues
KW - 3-amino-2-oxazolidinone
KW - furaltadone
KW - metabolites
KW - liver
KW - pigs
U2 - 10.1016/j.aca.2004.04.053
DO - 10.1016/j.aca.2004.04.053
M3 - Article
SN - 0003-2670
VL - 520
SP - 125
EP - 131
JO - Analytica Chimica Acta
JF - Analytica Chimica Acta
IS - 1-2
ER -
