Strigolactones (SLs) are new plant hormones with varies important bio-functions. This Letter deals with germination of seeds of parasitic weeds. Natural SLs have a too complex structure for synthesis. Therefore, there is an active search for SL analogues and mimics with a simpler structure with retention of activity. SL analogues all contain the D-ring connected with an enone moiety through an enol ether unit. A new mechanism for the hydrolysis SL analogues involving bidentate bound water and an a,ß-hydrolase with a Ser-His-Asp catalytic triad has been proposed. Newly discovered SL mimics only have the D-ring with an appropriate leaving group at C-5. A mode of action for SL mimics was proposed for which now supporting evidence is provided. As predicted an extra methyl group at C-4 of the D-ring blocks the germination of seeds of parasitic weeds.
- plant hormones
- am fungi
Zwanenburg, B., Nayak, S. K., Charnikhova, T., & Bouwmeester, H. J. (2013). New strigolactone mimics: structure-activity relationship and mode of action as germinating stimulants for parasitic weeds. Bioorganic and Medicinal Chemistry Letters, 23(18), 5182-5186. https://doi.org/10.1016/j.bmcl.2013.07.004