Abstract
Strigolactones (SLs) are new plant hormones with varies important bio-functions. This Letter deals with germination of seeds of parasitic weeds. Natural SLs have a too complex structure for synthesis. Therefore, there is an active search for SL analogues and mimics with a simpler structure with retention of activity. SL analogues all contain the D-ring connected with an enone moiety through an enol ether unit. A new mechanism for the hydrolysis SL analogues involving bidentate bound water and an a,ß-hydrolase with a Ser-His-Asp catalytic triad has been proposed. Newly discovered SL mimics only have the D-ring with an appropriate leaving group at C-5. A mode of action for SL mimics was proposed for which now supporting evidence is provided. As predicted an extra methyl group at C-4 of the D-ring blocks the germination of seeds of parasitic weeds.
Original language | English |
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Pages (from-to) | 5182-5186 |
Journal | Bioorganic and Medicinal Chemistry Letters |
Volume | 23 |
Issue number | 18 |
DOIs | |
Publication status | Published - 2013 |
Keywords
- seed-germination
- orobanche-minor
- plant hormones
- am fungi
- striga-hermonthica
- red-clover
- analogs
- inhibition
- ring
- phelipanche