New reports on iron related proteins: Molecular characterization of two ferroportin genes in common carp (Cyprinus carpio L.) and its expression pattern

Teresa Kamińska-Gibas, Joanna Szczygieł, Annemiek Blasweiler, Łukasz Gajda, Ebru Yilmaz, Patrycja Jurecka, Ludmiła Kolek, Marek Ples, Ilgiz Irnazarow*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Iron uptake, transport, and storage require the involvement of several proteins, including ferroportin (fpn), the sole known iron efflux transporter. Due to its critical function fpn has been studied, particularly in humans. Here, we characterized the ferroportin gene in common carp (Cyprinus carpio L.) and performed RNA-seq analysis to evaluate its constitutive transcription levels across different tissues. Our results indicate that C. carpio possesses two functional fpns with distinct expression patterns, highlighting the potential for functional divergence and expression differentiation among fpns in this species.

Original languageEnglish
Article number109087
JournalFish and Shellfish Immunology
Volume142
DOIs
Publication statusPublished - Nov 2023

Keywords

  • Common carp
  • Ferroportin
  • Gene expression
  • Hepcidin
  • Iron metabolism

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