New approach methodologies (NAMs) to study microbiome–host interactions

Chen Liu; Jing Jin; Ivonne M.C.M. Rietjens

doi:10.1016/j.cotox.2023.100406

New approach methodologies (NAMs) to study microbiome–host interactions

Chen Liu^*, Jing Jin, Ivonne M.C.M. Rietjens

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

1 Citation (Scopus)

Abstract

Gut microbiota plays an important role in host health and disease. They metabolize food-born chemicals, nutrients, drugs and other xenobiotics, while these chemicals and their metabolites can also modulate the gut microbiota. The present review provided an overview of the state-of-the-art in the application of in vitro and in silico based new approach methodologies (NAMs) to study these microbiome–host interactions in a non-invasive way and without the need for the use of animal or human studies.

Original language	English
Article number	100406
Journal	Current Opinion in Toxicology
Volume	35
DOIs	https://doi.org/10.1016/j.cotox.2023.100406
Publication status	Published - Sept 2023

Keywords

Gut microbiota
Gut-on-a-chip
Microbiome–host interaction
New approach methodologies (NAMs)
Physiologically based kinetic (PBK) model
Quantitative in vitro to in vivo extrapolation (QIVIVE)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.cotox.2023.100406

https://edepot.wur.nl/636263Licence: Taverne

Cite this

@article{04bfc3612a534774aae6fc45e598e341,

title = "New approach methodologies (NAMs) to study microbiome–host interactions",

abstract = "Gut microbiota plays an important role in host health and disease. They metabolize food-born chemicals, nutrients, drugs and other xenobiotics, while these chemicals and their metabolites can also modulate the gut microbiota. The present review provided an overview of the state-of-the-art in the application of in vitro and in silico based new approach methodologies (NAMs) to study these microbiome–host interactions in a non-invasive way and without the need for the use of animal or human studies.",

keywords = "Gut microbiota, Gut-on-a-chip, Microbiome–host interaction, New approach methodologies (NAMs), Physiologically based kinetic (PBK) model, Quantitative in vitro to in vivo extrapolation (QIVIVE)",

author = "Chen Liu and Jing Jin and Rietjens, {Ivonne M.C.M.}",

year = "2023",

month = sep,

doi = "10.1016/j.cotox.2023.100406",

language = "English",

volume = "35",

journal = "Current Opinion in Toxicology",

issn = "2468-2020",

publisher = "Elsevier",

}

TY - JOUR

T1 - New approach methodologies (NAMs) to study microbiome–host interactions

AU - Liu, Chen

AU - Jin, Jing

AU - Rietjens, Ivonne M.C.M.

PY - 2023/9

Y1 - 2023/9

N2 - Gut microbiota plays an important role in host health and disease. They metabolize food-born chemicals, nutrients, drugs and other xenobiotics, while these chemicals and their metabolites can also modulate the gut microbiota. The present review provided an overview of the state-of-the-art in the application of in vitro and in silico based new approach methodologies (NAMs) to study these microbiome–host interactions in a non-invasive way and without the need for the use of animal or human studies.

AB - Gut microbiota plays an important role in host health and disease. They metabolize food-born chemicals, nutrients, drugs and other xenobiotics, while these chemicals and their metabolites can also modulate the gut microbiota. The present review provided an overview of the state-of-the-art in the application of in vitro and in silico based new approach methodologies (NAMs) to study these microbiome–host interactions in a non-invasive way and without the need for the use of animal or human studies.

KW - Gut microbiota

KW - Gut-on-a-chip

KW - Microbiome–host interaction

KW - New approach methodologies (NAMs)

KW - Physiologically based kinetic (PBK) model

KW - Quantitative in vitro to in vivo extrapolation (QIVIVE)

U2 - 10.1016/j.cotox.2023.100406

DO - 10.1016/j.cotox.2023.100406

M3 - Article

AN - SCOPUS:85164275639

SN - 2468-2020

VL - 35

JO - Current Opinion in Toxicology

JF - Current Opinion in Toxicology

M1 - 100406

ER -

New approach methodologies (NAMs) to study microbiome–host interactions

Abstract

Keywords

UN SDGs

Access to Document

Fingerprint

Cite this