Neurotropic virus infections as the cause of immediate and delayed neuropathology

Martin Ludlow, Jeroen Kortekaas, Christiane Herden, Bernd Hoffmann, Dennis Tappe, Corinna Trebst, Diane E. Griffin, Hannah E. Brindle, Tom Solomon, Alan S. Brown, Debby van Riel, Katja C. Wolthers, Dasja Pajkrt, Peter Wohlsein, Byron E.E. Martina, Wolfgang Baumgärtner, Georges M. Verjans, Albert D.M.E. Osterhaus

Research output: Contribution to journalArticleAcademicpeer-review

58 Citations (Scopus)

Abstract

A wide range of viruses from different virus families in different geographical areas, may cause immediate or delayed neuropathological changes and neurological manifestations in humans and animals. Infection by neurotropic viruses as well as the resulting immune response can irreversibly disrupt the complex structural and functional architecture of the central nervous system, frequently leaving the patient or affected animal with a poor or fatal prognosis. Mechanisms that govern neuropathogenesis and immunopathogenesis of viral infections are highlighted, using examples of well-studied virus infections that are associated with these alterations in different populations throughout the world. A better understanding of the molecular, epidemiological and biological characteristics of these infections and in particular of mechanisms that underlie their clinical manifestations may be expected to provide tools for the development of more effective intervention strategies and treatment regimens.

Original languageEnglish
Pages (from-to)159-184
JournalActa Neuropathologica
Volume131
Issue number2
DOIs
Publication statusPublished - 2016

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Virus Diseases
Viruses
Neurologic Manifestations
Central Nervous System
Infection
Population
Neuropathology
Therapeutics

Keywords

  • Alphavirus
  • Bornavirus
  • Bunyavirus
  • Central nervous system
  • Flavivirus
  • Herpesvirus
  • Influenza virus
  • Neuroinfectiology
  • Neuropathology
  • Paramyxovirus
  • Picornavirus
  • Rhabdovirus
  • Virus infection

Cite this

Ludlow, M., Kortekaas, J., Herden, C., Hoffmann, B., Tappe, D., Trebst, C., ... Osterhaus, A. D. M. E. (2016). Neurotropic virus infections as the cause of immediate and delayed neuropathology. Acta Neuropathologica, 131(2), 159-184. https://doi.org/10.1007/s00401-015-1511-3
Ludlow, Martin ; Kortekaas, Jeroen ; Herden, Christiane ; Hoffmann, Bernd ; Tappe, Dennis ; Trebst, Corinna ; Griffin, Diane E. ; Brindle, Hannah E. ; Solomon, Tom ; Brown, Alan S. ; van Riel, Debby ; Wolthers, Katja C. ; Pajkrt, Dasja ; Wohlsein, Peter ; Martina, Byron E.E. ; Baumgärtner, Wolfgang ; Verjans, Georges M. ; Osterhaus, Albert D.M.E. / Neurotropic virus infections as the cause of immediate and delayed neuropathology. In: Acta Neuropathologica. 2016 ; Vol. 131, No. 2. pp. 159-184.
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abstract = "A wide range of viruses from different virus families in different geographical areas, may cause immediate or delayed neuropathological changes and neurological manifestations in humans and animals. Infection by neurotropic viruses as well as the resulting immune response can irreversibly disrupt the complex structural and functional architecture of the central nervous system, frequently leaving the patient or affected animal with a poor or fatal prognosis. Mechanisms that govern neuropathogenesis and immunopathogenesis of viral infections are highlighted, using examples of well-studied virus infections that are associated with these alterations in different populations throughout the world. A better understanding of the molecular, epidemiological and biological characteristics of these infections and in particular of mechanisms that underlie their clinical manifestations may be expected to provide tools for the development of more effective intervention strategies and treatment regimens.",
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Ludlow, M, Kortekaas, J, Herden, C, Hoffmann, B, Tappe, D, Trebst, C, Griffin, DE, Brindle, HE, Solomon, T, Brown, AS, van Riel, D, Wolthers, KC, Pajkrt, D, Wohlsein, P, Martina, BEE, Baumgärtner, W, Verjans, GM & Osterhaus, ADME 2016, 'Neurotropic virus infections as the cause of immediate and delayed neuropathology', Acta Neuropathologica, vol. 131, no. 2, pp. 159-184. https://doi.org/10.1007/s00401-015-1511-3

Neurotropic virus infections as the cause of immediate and delayed neuropathology. / Ludlow, Martin; Kortekaas, Jeroen; Herden, Christiane; Hoffmann, Bernd; Tappe, Dennis; Trebst, Corinna; Griffin, Diane E.; Brindle, Hannah E.; Solomon, Tom; Brown, Alan S.; van Riel, Debby; Wolthers, Katja C.; Pajkrt, Dasja; Wohlsein, Peter; Martina, Byron E.E.; Baumgärtner, Wolfgang; Verjans, Georges M.; Osterhaus, Albert D.M.E.

In: Acta Neuropathologica, Vol. 131, No. 2, 2016, p. 159-184.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Neurotropic virus infections as the cause of immediate and delayed neuropathology

AU - Ludlow, Martin

AU - Kortekaas, Jeroen

AU - Herden, Christiane

AU - Hoffmann, Bernd

AU - Tappe, Dennis

AU - Trebst, Corinna

AU - Griffin, Diane E.

AU - Brindle, Hannah E.

AU - Solomon, Tom

AU - Brown, Alan S.

AU - van Riel, Debby

AU - Wolthers, Katja C.

AU - Pajkrt, Dasja

AU - Wohlsein, Peter

AU - Martina, Byron E.E.

AU - Baumgärtner, Wolfgang

AU - Verjans, Georges M.

AU - Osterhaus, Albert D.M.E.

PY - 2016

Y1 - 2016

N2 - A wide range of viruses from different virus families in different geographical areas, may cause immediate or delayed neuropathological changes and neurological manifestations in humans and animals. Infection by neurotropic viruses as well as the resulting immune response can irreversibly disrupt the complex structural and functional architecture of the central nervous system, frequently leaving the patient or affected animal with a poor or fatal prognosis. Mechanisms that govern neuropathogenesis and immunopathogenesis of viral infections are highlighted, using examples of well-studied virus infections that are associated with these alterations in different populations throughout the world. A better understanding of the molecular, epidemiological and biological characteristics of these infections and in particular of mechanisms that underlie their clinical manifestations may be expected to provide tools for the development of more effective intervention strategies and treatment regimens.

AB - A wide range of viruses from different virus families in different geographical areas, may cause immediate or delayed neuropathological changes and neurological manifestations in humans and animals. Infection by neurotropic viruses as well as the resulting immune response can irreversibly disrupt the complex structural and functional architecture of the central nervous system, frequently leaving the patient or affected animal with a poor or fatal prognosis. Mechanisms that govern neuropathogenesis and immunopathogenesis of viral infections are highlighted, using examples of well-studied virus infections that are associated with these alterations in different populations throughout the world. A better understanding of the molecular, epidemiological and biological characteristics of these infections and in particular of mechanisms that underlie their clinical manifestations may be expected to provide tools for the development of more effective intervention strategies and treatment regimens.

KW - Alphavirus

KW - Bornavirus

KW - Bunyavirus

KW - Central nervous system

KW - Flavivirus

KW - Herpesvirus

KW - Influenza virus

KW - Neuroinfectiology

KW - Neuropathology

KW - Paramyxovirus

KW - Picornavirus

KW - Rhabdovirus

KW - Virus infection

U2 - 10.1007/s00401-015-1511-3

DO - 10.1007/s00401-015-1511-3

M3 - Article

VL - 131

SP - 159

EP - 184

JO - Acta Neuropathologica

JF - Acta Neuropathologica

SN - 0001-6322

IS - 2

ER -