Neurotropic virus infections as the cause of immediate and delayed neuropathology

Martin Ludlow; Jeroen Kortekaas; Christiane Herden; Bernd Hoffmann; Dennis Tappe; Corinna Trebst; Diane E. Griffin; Hannah E. Brindle; Tom Solomon; Alan S. Brown; Debby van Riel; Katja C. Wolthers; Dasja Pajkrt; Peter Wohlsein; Byron E.E. Martina; Wolfgang Baumgärtner; Georges M. Verjans; Albert D.M.E. Osterhaus

doi:10.1007/s00401-015-1511-3

Neurotropic virus infections as the cause of immediate and delayed neuropathology

Martin Ludlow, Jeroen Kortekaas, Christiane Herden, Bernd Hoffmann, Dennis Tappe, Corinna Trebst, Diane E. Griffin, Hannah E. Brindle, Tom Solomon, Alan S. Brown, Debby van Riel, Katja C. Wolthers, Dasja Pajkrt, Peter Wohlsein, Byron E.E. Martina, Wolfgang Baumgärtner, Georges M. Verjans, Albert D.M.E. Osterhaus^*

^*Corresponding author for this work

Virology & Molecular Biology

Research output: Contribution to journal › Article › Academic › peer-review

174 Citations (Scopus)

Abstract

A wide range of viruses from different virus families in different geographical areas, may cause immediate or delayed neuropathological changes and neurological manifestations in humans and animals. Infection by neurotropic viruses as well as the resulting immune response can irreversibly disrupt the complex structural and functional architecture of the central nervous system, frequently leaving the patient or affected animal with a poor or fatal prognosis. Mechanisms that govern neuropathogenesis and immunopathogenesis of viral infections are highlighted, using examples of well-studied virus infections that are associated with these alterations in different populations throughout the world. A better understanding of the molecular, epidemiological and biological characteristics of these infections and in particular of mechanisms that underlie their clinical manifestations may be expected to provide tools for the development of more effective intervention strategies and treatment regimens.

Original language	English
Pages (from-to)	159-184
Journal	Acta Neuropathologica
Volume	131
Issue number	2
DOIs	https://doi.org/10.1007/s00401-015-1511-3
Publication status	Published - 2016

Keywords

Alphavirus
Bornavirus
Bunyavirus
Central nervous system
Flavivirus
Herpesvirus
Influenza virus
Neuroinfectiology
Neuropathology
Paramyxovirus
Picornavirus
Rhabdovirus
Virus infection

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10.1007/s00401-015-1511-3Licence: CC BY

Virale zoönosen en vectorgebonden ziekten (WOT-01-002-041, WOT-01-003-015)
Holwerda, M.
1/01/08 → 31/12/23
Project: EZproject

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Ludlow, M., Kortekaas, J., Herden, C., Hoffmann, B., Tappe, D., Trebst, C., Griffin, D. E., Brindle, H. E., Solomon, T., Brown, A. S., van Riel, D., Wolthers, K. C., Pajkrt, D., Wohlsein, P., Martina, B. E. E., Baumgärtner, W., Verjans, G. M., & Osterhaus, A. D. M. E. (2016). Neurotropic virus infections as the cause of immediate and delayed neuropathology. Acta Neuropathologica, 131(2), 159-184. https://doi.org/10.1007/s00401-015-1511-3

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title = "Neurotropic virus infections as the cause of immediate and delayed neuropathology",

abstract = "A wide range of viruses from different virus families in different geographical areas, may cause immediate or delayed neuropathological changes and neurological manifestations in humans and animals. Infection by neurotropic viruses as well as the resulting immune response can irreversibly disrupt the complex structural and functional architecture of the central nervous system, frequently leaving the patient or affected animal with a poor or fatal prognosis. Mechanisms that govern neuropathogenesis and immunopathogenesis of viral infections are highlighted, using examples of well-studied virus infections that are associated with these alterations in different populations throughout the world. A better understanding of the molecular, epidemiological and biological characteristics of these infections and in particular of mechanisms that underlie their clinical manifestations may be expected to provide tools for the development of more effective intervention strategies and treatment regimens.",

keywords = "Alphavirus, Bornavirus, Bunyavirus, Central nervous system, Flavivirus, Herpesvirus, Influenza virus, Neuroinfectiology, Neuropathology, Paramyxovirus, Picornavirus, Rhabdovirus, Virus infection",

author = "Martin Ludlow and Jeroen Kortekaas and Christiane Herden and Bernd Hoffmann and Dennis Tappe and Corinna Trebst and Griffin, {Diane E.} and Brindle, {Hannah E.} and Tom Solomon and Brown, {Alan S.} and {van Riel}, Debby and Wolthers, {Katja C.} and Dasja Pajkrt and Peter Wohlsein and Martina, {Byron E.E.} and Wolfgang Baumg{\"a}rtner and Verjans, {Georges M.} and Osterhaus, {Albert D.M.E.}",

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doi = "10.1007/s00401-015-1511-3",

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Ludlow, M, Kortekaas, J, Herden, C, Hoffmann, B, Tappe, D, Trebst, C, Griffin, DE, Brindle, HE, Solomon, T, Brown, AS, van Riel, D, Wolthers, KC, Pajkrt, D, Wohlsein, P, Martina, BEE, Baumgärtner, W, Verjans, GM & Osterhaus, ADME 2016, 'Neurotropic virus infections as the cause of immediate and delayed neuropathology', Acta Neuropathologica, vol. 131, no. 2, pp. 159-184. https://doi.org/10.1007/s00401-015-1511-3

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T1 - Neurotropic virus infections as the cause of immediate and delayed neuropathology

AU - Ludlow, Martin

AU - Kortekaas, Jeroen

AU - Herden, Christiane

AU - Hoffmann, Bernd

AU - Tappe, Dennis

AU - Trebst, Corinna

AU - Griffin, Diane E.

AU - Brindle, Hannah E.

AU - Solomon, Tom

AU - Brown, Alan S.

AU - van Riel, Debby

AU - Wolthers, Katja C.

AU - Pajkrt, Dasja

AU - Wohlsein, Peter

AU - Martina, Byron E.E.

AU - Baumgärtner, Wolfgang

AU - Verjans, Georges M.

AU - Osterhaus, Albert D.M.E.

PY - 2016

Y1 - 2016

N2 - A wide range of viruses from different virus families in different geographical areas, may cause immediate or delayed neuropathological changes and neurological manifestations in humans and animals. Infection by neurotropic viruses as well as the resulting immune response can irreversibly disrupt the complex structural and functional architecture of the central nervous system, frequently leaving the patient or affected animal with a poor or fatal prognosis. Mechanisms that govern neuropathogenesis and immunopathogenesis of viral infections are highlighted, using examples of well-studied virus infections that are associated with these alterations in different populations throughout the world. A better understanding of the molecular, epidemiological and biological characteristics of these infections and in particular of mechanisms that underlie their clinical manifestations may be expected to provide tools for the development of more effective intervention strategies and treatment regimens.

AB - A wide range of viruses from different virus families in different geographical areas, may cause immediate or delayed neuropathological changes and neurological manifestations in humans and animals. Infection by neurotropic viruses as well as the resulting immune response can irreversibly disrupt the complex structural and functional architecture of the central nervous system, frequently leaving the patient or affected animal with a poor or fatal prognosis. Mechanisms that govern neuropathogenesis and immunopathogenesis of viral infections are highlighted, using examples of well-studied virus infections that are associated with these alterations in different populations throughout the world. A better understanding of the molecular, epidemiological and biological characteristics of these infections and in particular of mechanisms that underlie their clinical manifestations may be expected to provide tools for the development of more effective intervention strategies and treatment regimens.

KW - Alphavirus

KW - Bornavirus

KW - Bunyavirus

KW - Central nervous system

KW - Flavivirus

KW - Herpesvirus

KW - Influenza virus

KW - Neuroinfectiology

KW - Neuropathology

KW - Paramyxovirus

KW - Picornavirus

KW - Rhabdovirus

KW - Virus infection

U2 - 10.1007/s00401-015-1511-3

DO - 10.1007/s00401-015-1511-3

M3 - Article

SN - 0001-6322

VL - 131

SP - 159

EP - 184

JO - Acta Neuropathologica

JF - Acta Neuropathologica

IS - 2

ER -

Neurotropic virus infections as the cause of immediate and delayed neuropathology

Abstract

Keywords

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Virale zoönosen en vectorgebonden ziekten (WOT-01-002-041, WOT-01-003-015)

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