Neurotropic virus infections as the cause of immediate and delayed neuropathology

Martin Ludlow, Jeroen Kortekaas, Christiane Herden, Bernd Hoffmann, Dennis Tappe, Corinna Trebst, Diane E. Griffin, Hannah E. Brindle, Tom Solomon, Alan S. Brown, Debby van Riel, Katja C. Wolthers, Dasja Pajkrt, Peter Wohlsein, Byron E.E. Martina, Wolfgang Baumgärtner, Georges M. Verjans, Albert D.M.E. Osterhaus*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

174 Citations (Scopus)


A wide range of viruses from different virus families in different geographical areas, may cause immediate or delayed neuropathological changes and neurological manifestations in humans and animals. Infection by neurotropic viruses as well as the resulting immune response can irreversibly disrupt the complex structural and functional architecture of the central nervous system, frequently leaving the patient or affected animal with a poor or fatal prognosis. Mechanisms that govern neuropathogenesis and immunopathogenesis of viral infections are highlighted, using examples of well-studied virus infections that are associated with these alterations in different populations throughout the world. A better understanding of the molecular, epidemiological and biological characteristics of these infections and in particular of mechanisms that underlie their clinical manifestations may be expected to provide tools for the development of more effective intervention strategies and treatment regimens.

Original languageEnglish
Pages (from-to)159-184
JournalActa Neuropathologica
Issue number2
Publication statusPublished - 2016


  • Alphavirus
  • Bornavirus
  • Bunyavirus
  • Central nervous system
  • Flavivirus
  • Herpesvirus
  • Influenza virus
  • Neuroinfectiology
  • Neuropathology
  • Paramyxovirus
  • Picornavirus
  • Rhabdovirus
  • Virus infection


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