Neuroendocrine modulation of the inflammatory response in common carp: adrenaline regulates leukocyte profile and activity

M. Kepka, B.M.L. Verburg-van Kemenade, M.K. Chadzinska

Research output: Contribution to journalArticleAcademicpeer-review

12 Citations (Scopus)

Abstract

Inflammatory responses have to be carefully controlled, as high concentrations and/or prolonged action of inflammation-related molecules (e.g. reactive oxygen species, nitric oxide and pro-inflammatory cytokines) can be detrimental to host tissue and organs. One of the potential regulators of the inflammatory process are stress mediators including adrenaline. In vivo effects of adrenaline were studied during zymosan-induced (Z) peritoneal inflammation in the common carp Cyprinus carpio L. Adrenaline injected together with zymosan (ZA) did not change the number of inflammatory leukocytes in the peritoneal cavity, however at 24 h post-injection it significantly reduced the percentage of monocytes/macrophages. Moreover, compared to cells retrieved from fish treated with PBS or zymosan only, adrenaline increased the percentage of apoptotic leukocytes in the focus of inflammation. Furthermore, adrenaline significantly reduced the expression of chemokine CXCL8_L1 (a functional homolog of mammalian IL-8) and its receptors (CXCR1 and CXCR2), indicating changes in leukocyte recruitment after stress. We conclude that adrenaline may contribute to a coordinated reaction by influencing the inflammatory response via direct regulation of leukocyte migration and/or apoptosis.
Original languageEnglish
Pages (from-to)102-109
JournalGeneral and Comparative Endocrinology
Volume188
DOIs
Publication statusPublished - 2013

Keywords

  • beta-adrenergic-receptors
  • necrosis-factor-alpha
  • cyprinus-carpio
  • in-vitro
  • immune-response
  • rainbow-trout
  • neutrophilic granulocytes
  • interleukin-10 production
  • opioid receptor
  • nervous-system

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