Neuroendocrine-immune interaction in teleost fish

B.M.L. Verburg-van Kemenade, H.H. Stolte, M.K. Chadzinska

Research output: Chapter in Book/Report/Conference proceedingAbstract

Abstract

Bi-directional communication between the hypothalamus-pituitary-adrenal (HPA)-axis and the sympathetic nervous system with the immune system is crucial to ensure homeostasis. Shared use of ligands and especially receptors forms a key component of this bi-directional interaction. Glucocorticoids (GC), the major end products of the HPA-axis differentially modulate immune function. Cytokines, especially interleukin-1 (IL-1), tumour necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6), ensure immune signalling to the neuroendocrine system. In addition, hormones from leukocyte origin such as corticotropin-releasing hormone (CRH), adrenocorticotropic hormone (ACTH) and beta-endorphin, as well as centrally synthesised and secreted cytokines, contribute to the communication network.In teleost fish cortisol is the major product of the hypothalamus-pituitary-interrenal (HPI)-axis which is the teleost equivalent of the HPA-axis. Moderate and substantial increases in cortisol during stressful circumstances negatively affect B-lymphocytes, whereas rescue of neutrophilic granulocytes may support innate immunity. Recent elucidation of lower vertebrate cytokine sequences has facilitated research into neuroendocrine-immune interactions in teleosts and the first evidence for a significant function of interleukin-1 in the bi-directional communication is discussed.
Original languageEnglish
Title of host publicationBook of Abstracts XIII Congress of Polish Society of Experimental and Clinical Immunology, Krakow, Loland, 14 - 17 May, 2008
Pages176
Volume33
Publication statusPublished - 2008
EventXIII Congress of Polish Society of Experimental and Clinical Immunology -
Duration: 14 May 200817 May 2008

Conference

ConferenceXIII Congress of Polish Society of Experimental and Clinical Immunology
Period14/05/0817/05/08

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  • Cite this

    Verburg-van Kemenade, B. M. L., Stolte, H. H., & Chadzinska, M. K. (2008). Neuroendocrine-immune interaction in teleost fish. In Book of Abstracts XIII Congress of Polish Society of Experimental and Clinical Immunology, Krakow, Loland, 14 - 17 May, 2008 (Vol. 33, pp. 176)