Network approaches for plant phylogenomic synteny analysis

Network analysis approaches have been widely applied across disciplines. In biology, network analysis is now frequently adopted to organize protein–protein interactions, organize pathways and/or to interpret gene co-expression patterns. However, comparative genomic analyses still largely rely on pairwise comparisons and linear visualizations between genomes. In this article, we discuss the challenges and prospects for establishing a generalized plant phylogenomic synteny network approach needed to interpret the wealth of new and emerging genomic data. We illustrate our approach with an example synteny network of B-class floral MADS-box genes. A broad synteny network approach holds great promise for understanding the evolutionary history of genes and genomes across broad phylogenetic groups and divergence times.