Natural functions of lipopeptides from Bacillus and Pseudomonas: more than surfactants and antibiotics

J.M. Raaijmakers, I. de Bruijn, O. Nybroe, M. Ongena

Research output: Contribution to journalArticleAcademicpeer-review

544 Citations (Scopus)

Abstract

Lipopeptides constitute a structurally diverse group of metabolites produced by various bacterial and fungal genera. In the past decades, research on lipopeptides has been fueled by their antimicrobial, antitumour, immunosuppressant and surfactant activities. However, the natural functions of lipopeptides in the lifestyles of the producing microorganisms have received considerably less attention. The substantial structural diversity of lipopeptides suggests that these metabolites have different natural roles, some of which may be unique to the biology of the producing organism. This review gives a detailed overview of the versatile functions of lipopeptides in the biology of Pseudomonas and Bacillus species, and highlights their role in competitive interactions with coexisting organisms, including bacteria, fungi, oomycetes, protozoa, nematodes and plants. Their functions in cell motility, leading to colonization of novel habitats, and in the formation and development of highly structured biofilms are discussed in detail. Finally, this review provides an update on lipopeptide detection and discovery as well as on novel regulatory mechanisms and genes involved in lipopeptide biosynthesis in these two bacterial genera.
Original languageEnglish
Pages (from-to)1037-1062
JournalFEMS Microbiology Reviews
Volume34
Issue number6
DOIs
Publication statusPublished - 2010

Keywords

  • syringae pv syringae
  • nonribosomal peptide synthetases
  • plant signal molecules
  • sugar-beet rhizosphere
  • ultrashort cationic lipopeptides
  • enterica serovar typhimurium
  • serratia-liquefaciens mg1
  • brown blotch disease
  • subtilis okb 105
  • sp strain dss73

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