Nanoparticle tracking analysis of gold nanoparticles in aqueous media through an inter-laboratory comparison

Sophie M. Briffa, Jo Sullivan, Agnieszka Siupa, Pauline Carnell-Morris, Michele Carboni, Kerstin Jurkschat, Ruud J.B. Peters, Carolin Schultz, Kang Hee Seol, Sook Jin Kwon, Sehee Park, Tae Hyun Yoon, Colin Johnston, Stephen Lofts, Eugenia Valsami-Jones

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

In the field of nanotechnology, analytical characterization plays a vital role in understanding the behavior and toxicity of nanomaterials (NMs). Characterization needs to be thorough and the technique chosen should be well-suited to the property to be determined, the material being analyzed and the medium in which it is present. Furthermore, the instrument operation and methodology need to be well-developed and clearly understood by the user to avoid data collection errors. Any discrepancies in the applied method or procedure can lead to differences and poor reproducibility of obtained data. This paper aims to clarify the method to measure the hydrodynamic diameter of gold nanoparticles by means of Nanoparticle Tracking Analysis (NTA). This study was carried out as an inter-laboratory comparison (ILC) amongst seven different laboratories to validate the standard operating procedure’s performance and reproducibility. The results obtained from this ILC study reveal the importance and benefits of detailed standard operating procedures (SOPs), best practice updates, user knowledge, and measurement automation.

Original languageEnglish
Article numbere61741
Number of pages12
JournalJournal of Visualized Experiments
Volume2020
Issue number164
DOIs
Publication statusPublished - Oct 2020

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