Myricetin stimulates the absorption of the pro-carcinogen PhIP

M.E. Schutte; J.J.M. van de Sandt; G.M. Alink; J.P. Groten; I.M.C.M. Rietjens

doi:10.1016/j.canlet.2005.01.020

Myricetin stimulates the absorption of the pro-carcinogen PhIP

M.E. Schutte
, J.J.M. van de Sandt
, G.M. Alink
, J.P. Groten
, I.M.C.M. Rietjens

Research output: Contribution to journal › Article › Academic › peer-review

18 Citations (Scopus)

Abstract

The effect of the flavonoid myricetin on the transport of the pro-carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) through differentiated Caco-2 monolayers, a model for the intestinal epithelium, is described. Myricetin causes an increase of the transport of PhIP from the apical to the basolateral compartment. This effect was observed at physiologically relevant concentrations of PhIP and myricetin. Cyclosporin A (MRP2 inhibitor) but not PSC833 (P-gp inhibitor) showed a similar effect on PhIP transport. The results indicate that myricetin induces an increased basolateral uptake of the pro-carcinogen PhIP, in part through inhibition of the MRP2 mediated excretion of PhIP from the intestinal cells back to the lumen

Original language	English
Pages (from-to)	36-42
Journal	Cancer Letters
Volume	231
Issue number	1
DOIs	https://doi.org/10.1016/j.canlet.2005.01.020
Publication status	Published - 2006

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

potentially anticarcinogenic flavonoids
multidrug-resistance protein-1
apparent drug permeability
caco-2
expression
cells
transport
localization
modulation
mutagen

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10.1016/j.canlet.2005.01.020

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@article{3939ca1e6a404677b6e4b57307614121,

title = "Myricetin stimulates the absorption of the pro-carcinogen PhIP",

abstract = "The effect of the flavonoid myricetin on the transport of the pro-carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) through differentiated Caco-2 monolayers, a model for the intestinal epithelium, is described. Myricetin causes an increase of the transport of PhIP from the apical to the basolateral compartment. This effect was observed at physiologically relevant concentrations of PhIP and myricetin. Cyclosporin A (MRP2 inhibitor) but not PSC833 (P-gp inhibitor) showed a similar effect on PhIP transport. The results indicate that myricetin induces an increased basolateral uptake of the pro-carcinogen PhIP, in part through inhibition of the MRP2 mediated excretion of PhIP from the intestinal cells back to the lumen",

keywords = "potentially anticarcinogenic flavonoids, multidrug-resistance protein-1, apparent drug permeability, caco-2, expression, cells, transport, localization, modulation, mutagen",

author = "M.E. Schutte and \{van de Sandt\}, J.J.M. and G.M. Alink and J.P. Groten and I.M.C.M. Rietjens",

year = "2006",

doi = "10.1016/j.canlet.2005.01.020",

language = "English",

volume = "231",

pages = "36--42",

journal = "Cancer Letters",

issn = "0304-3835",

publisher = "Elsevier",

number = "1",

}

TY - JOUR

T1 - Myricetin stimulates the absorption of the pro-carcinogen PhIP

AU - Schutte, M.E.

AU - van de Sandt, J.J.M.

AU - Alink, G.M.

AU - Groten, J.P.

AU - Rietjens, I.M.C.M.

PY - 2006

Y1 - 2006

N2 - The effect of the flavonoid myricetin on the transport of the pro-carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) through differentiated Caco-2 monolayers, a model for the intestinal epithelium, is described. Myricetin causes an increase of the transport of PhIP from the apical to the basolateral compartment. This effect was observed at physiologically relevant concentrations of PhIP and myricetin. Cyclosporin A (MRP2 inhibitor) but not PSC833 (P-gp inhibitor) showed a similar effect on PhIP transport. The results indicate that myricetin induces an increased basolateral uptake of the pro-carcinogen PhIP, in part through inhibition of the MRP2 mediated excretion of PhIP from the intestinal cells back to the lumen

AB - The effect of the flavonoid myricetin on the transport of the pro-carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) through differentiated Caco-2 monolayers, a model for the intestinal epithelium, is described. Myricetin causes an increase of the transport of PhIP from the apical to the basolateral compartment. This effect was observed at physiologically relevant concentrations of PhIP and myricetin. Cyclosporin A (MRP2 inhibitor) but not PSC833 (P-gp inhibitor) showed a similar effect on PhIP transport. The results indicate that myricetin induces an increased basolateral uptake of the pro-carcinogen PhIP, in part through inhibition of the MRP2 mediated excretion of PhIP from the intestinal cells back to the lumen

KW - potentially anticarcinogenic flavonoids

KW - multidrug-resistance protein-1

KW - apparent drug permeability

KW - caco-2

KW - expression

KW - cells

KW - transport

KW - localization

KW - modulation

KW - mutagen

U2 - 10.1016/j.canlet.2005.01.020

DO - 10.1016/j.canlet.2005.01.020

M3 - Article

SN - 0304-3835

VL - 231

SP - 36

EP - 42

JO - Cancer Letters

JF - Cancer Letters

IS - 1

ER -

Myricetin stimulates the absorption of the pro-carcinogen PhIP

Abstract

UN SDGs

Keywords

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