Myricetin stimulates the absorption of the pro-carcinogen PhIP

M.E. Schutte, J.J.M. van de Sandt, G.M. Alink, J.P. Groten, I.M.C.M. Rietjens

Research output: Contribution to journalArticleAcademicpeer-review

15 Citations (Scopus)

Abstract

The effect of the flavonoid myricetin on the transport of the pro-carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) through differentiated Caco-2 monolayers, a model for the intestinal epithelium, is described. Myricetin causes an increase of the transport of PhIP from the apical to the basolateral compartment. This effect was observed at physiologically relevant concentrations of PhIP and myricetin. Cyclosporin A (MRP2 inhibitor) but not PSC833 (P-gp inhibitor) showed a similar effect on PhIP transport. The results indicate that myricetin induces an increased basolateral uptake of the pro-carcinogen PhIP, in part through inhibition of the MRP2 mediated excretion of PhIP from the intestinal cells back to the lumen
Original languageEnglish
Pages (from-to)36-42
JournalCancer Letters
Volume231
Issue number1
DOIs
Publication statusPublished - 2006

Keywords

  • potentially anticarcinogenic flavonoids
  • multidrug-resistance protein-1
  • apparent drug permeability
  • caco-2
  • expression
  • cells
  • transport
  • localization
  • modulation
  • mutagen

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