Mucus and gut barrier in health and disease

B. Sovran

Research output: Thesisinternal PhD, WU

Abstract

This publication describes his work as a PhD student in the Host-Microbe Interactomics Chair group at Wageningen University within the Gastrointestinal Health theme. It has been completed under the supervision of Prof. Dr Jerry M Wells, Dr Jan Dekker and the TIFN project leader, Prof. Dr Paul de Vos.

Mucus serves as a protective layer between the intestinal content and the intestinal wall. It facilitates the passage of the luminal content through the intestine, reducing the risk of mechanical damage to the intestinal epithelium. The overarching goal of this thesis was to investigate the role of mucus in the maintenance of the intestinal immune barrier and the effects of ageing and gender differences on mucus production and the gut barrier.

We found by using a mouse model that decreased mucus production leads to changes in microbiota and mucosal stress responses, without the appearance of pathology, demonstrating the importance of mucus in intestinal homeostasis. The mucus barrier was shown to deteriorate during aging but this could be prevented with specific probiotics. Furthermore gender-specific differences in the effects of ageing on the mucosal barrier were found. Increased knowledge on these mechanisms might contribute significantly to disease prevention and treatment, for instance by optimizing gender-specific dietary and pharmacological requirements.  

The study presented in this thesis was performed within the framework of Top Institute Food and Nutrition, within the GH002 project.

 

Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • Wageningen University
Supervisors/Advisors
  • Wells, Jerry, Promotor
  • de Vos, P., Promotor, External person
  • Dekker, J., Co-promotor, External person
Award date23 Oct 2015
Place of PublicationWageningen
Publisher
Print ISBNs9789462574892
Publication statusPublished - 2015

Fingerprint

Mucus
Health
Nutritional Requirements
Gastrointestinal Contents
Microbiota
Probiotics
Intestinal Mucosa
Intestines
Homeostasis
Maintenance
Pharmacology
Pathology
Students
Food

Keywords

  • mucus
  • digestive tract
  • intestines
  • mice
  • probiotics
  • peyer patches
  • colitis
  • transcriptomes
  • immunohistology
  • senescence
  • sex
  • homeostasis
  • health
  • diseases

Cite this

Sovran, B. (2015). Mucus and gut barrier in health and disease. Wageningen: Wageningen University.
Sovran, B.. / Mucus and gut barrier in health and disease. Wageningen : Wageningen University, 2015. 233 p.
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Sovran, B 2015, 'Mucus and gut barrier in health and disease', Doctor of Philosophy, Wageningen University, Wageningen.

Mucus and gut barrier in health and disease. / Sovran, B.

Wageningen : Wageningen University, 2015. 233 p.

Research output: Thesisinternal PhD, WU

TY - THES

T1 - Mucus and gut barrier in health and disease

AU - Sovran, B.

N1 - WU thesis, no. 6174

PY - 2015

Y1 - 2015

N2 - This publication describes his work as a PhD student in the Host-Microbe Interactomics Chair group at Wageningen University within the Gastrointestinal Health theme. It has been completed under the supervision of Prof. Dr Jerry M Wells, Dr Jan Dekker and the TIFN project leader, Prof. Dr Paul de Vos. Mucus serves as a protective layer between the intestinal content and the intestinal wall. It facilitates the passage of the luminal content through the intestine, reducing the risk of mechanical damage to the intestinal epithelium. The overarching goal of this thesis was to investigate the role of mucus in the maintenance of the intestinal immune barrier and the effects of ageing and gender differences on mucus production and the gut barrier. We found by using a mouse model that decreased mucus production leads to changes in microbiota and mucosal stress responses, without the appearance of pathology, demonstrating the importance of mucus in intestinal homeostasis. The mucus barrier was shown to deteriorate during aging but this could be prevented with specific probiotics. Furthermore gender-specific differences in the effects of ageing on the mucosal barrier were found. Increased knowledge on these mechanisms might contribute significantly to disease prevention and treatment, for instance by optimizing gender-specific dietary and pharmacological requirements.   The study presented in this thesis was performed within the framework of Top Institute Food and Nutrition, within the GH002 project.  

AB - This publication describes his work as a PhD student in the Host-Microbe Interactomics Chair group at Wageningen University within the Gastrointestinal Health theme. It has been completed under the supervision of Prof. Dr Jerry M Wells, Dr Jan Dekker and the TIFN project leader, Prof. Dr Paul de Vos. Mucus serves as a protective layer between the intestinal content and the intestinal wall. It facilitates the passage of the luminal content through the intestine, reducing the risk of mechanical damage to the intestinal epithelium. The overarching goal of this thesis was to investigate the role of mucus in the maintenance of the intestinal immune barrier and the effects of ageing and gender differences on mucus production and the gut barrier. We found by using a mouse model that decreased mucus production leads to changes in microbiota and mucosal stress responses, without the appearance of pathology, demonstrating the importance of mucus in intestinal homeostasis. The mucus barrier was shown to deteriorate during aging but this could be prevented with specific probiotics. Furthermore gender-specific differences in the effects of ageing on the mucosal barrier were found. Increased knowledge on these mechanisms might contribute significantly to disease prevention and treatment, for instance by optimizing gender-specific dietary and pharmacological requirements.   The study presented in this thesis was performed within the framework of Top Institute Food and Nutrition, within the GH002 project.  

KW - slijm

KW - spijsverteringskanaal

KW - darmen

KW - muizen

KW - probiotica

KW - eilandjes van peyer

KW - colitis

KW - transcriptomen

KW - immunohistologie

KW - veroudering

KW - geslacht (sex)

KW - homeostase

KW - gezondheid

KW - ziekten

KW - mucus

KW - digestive tract

KW - intestines

KW - mice

KW - probiotics

KW - peyer patches

KW - colitis

KW - transcriptomes

KW - immunohistology

KW - senescence

KW - sex

KW - homeostasis

KW - health

KW - diseases

M3 - internal PhD, WU

SN - 9789462574892

PB - Wageningen University

CY - Wageningen

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Sovran B. Mucus and gut barrier in health and disease. Wageningen: Wageningen University, 2015. 233 p.