Abstract
This publication describes his work as a PhD student in the Host-Microbe Interactomics Chair group at Wageningen University within the Gastrointestinal Health theme. It has been completed under the supervision of Prof. Dr Jerry M Wells, Dr Jan Dekker and the TIFN project leader, Prof. Dr Paul de Vos.
Mucus serves as a protective layer between the intestinal content and the intestinal wall. It facilitates the passage of the luminal content through the intestine, reducing the risk of mechanical damage to the intestinal epithelium. The overarching goal of this thesis was to investigate the role of mucus in the maintenance of the intestinal immune barrier and the effects of ageing and gender differences on mucus production and the gut barrier.
We found by using a mouse model that decreased mucus production leads to changes in microbiota and mucosal stress responses, without the appearance of pathology, demonstrating the importance of mucus in intestinal homeostasis. The mucus barrier was shown to deteriorate during aging but this could be prevented with specific probiotics. Furthermore gender-specific differences in the effects of ageing on the mucosal barrier were found. Increased knowledge on these mechanisms might contribute significantly to disease prevention and treatment, for instance by optimizing gender-specific dietary and pharmacological requirements.
The study presented in this thesis was performed within the framework of Top Institute Food and Nutrition, within the GH002 project.
| Original language | English |
|---|---|
| Qualification | Doctor of Philosophy |
| Awarding Institution |
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| Supervisors/Advisors |
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| Award date | 23 Oct 2015 |
| Place of Publication | Wageningen |
| Publisher | |
| Print ISBNs | 9789462574892 |
| Publication status | Published - 2015 |
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Keywords
- mucus
- digestive tract
- intestines
- mice
- probiotics
- peyer patches
- colitis
- transcriptomes
- immunohistology
- senescence
- sex
- homeostasis
- health
- diseases
Cite this
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Mucus and gut barrier in health and disease. / Sovran, B.
Wageningen : Wageningen University, 2015. 233 p.Research output: Thesis › internal PhD, WU
TY - THES
T1 - Mucus and gut barrier in health and disease
AU - Sovran, B.
N1 - WU thesis, no. 6174
PY - 2015
Y1 - 2015
N2 - This publication describes his work as a PhD student in the Host-Microbe Interactomics Chair group at Wageningen University within the Gastrointestinal Health theme. It has been completed under the supervision of Prof. Dr Jerry M Wells, Dr Jan Dekker and the TIFN project leader, Prof. Dr Paul de Vos. Mucus serves as a protective layer between the intestinal content and the intestinal wall. It facilitates the passage of the luminal content through the intestine, reducing the risk of mechanical damage to the intestinal epithelium. The overarching goal of this thesis was to investigate the role of mucus in the maintenance of the intestinal immune barrier and the effects of ageing and gender differences on mucus production and the gut barrier. We found by using a mouse model that decreased mucus production leads to changes in microbiota and mucosal stress responses, without the appearance of pathology, demonstrating the importance of mucus in intestinal homeostasis. The mucus barrier was shown to deteriorate during aging but this could be prevented with specific probiotics. Furthermore gender-specific differences in the effects of ageing on the mucosal barrier were found. Increased knowledge on these mechanisms might contribute significantly to disease prevention and treatment, for instance by optimizing gender-specific dietary and pharmacological requirements. The study presented in this thesis was performed within the framework of Top Institute Food and Nutrition, within the GH002 project.
AB - This publication describes his work as a PhD student in the Host-Microbe Interactomics Chair group at Wageningen University within the Gastrointestinal Health theme. It has been completed under the supervision of Prof. Dr Jerry M Wells, Dr Jan Dekker and the TIFN project leader, Prof. Dr Paul de Vos. Mucus serves as a protective layer between the intestinal content and the intestinal wall. It facilitates the passage of the luminal content through the intestine, reducing the risk of mechanical damage to the intestinal epithelium. The overarching goal of this thesis was to investigate the role of mucus in the maintenance of the intestinal immune barrier and the effects of ageing and gender differences on mucus production and the gut barrier. We found by using a mouse model that decreased mucus production leads to changes in microbiota and mucosal stress responses, without the appearance of pathology, demonstrating the importance of mucus in intestinal homeostasis. The mucus barrier was shown to deteriorate during aging but this could be prevented with specific probiotics. Furthermore gender-specific differences in the effects of ageing on the mucosal barrier were found. Increased knowledge on these mechanisms might contribute significantly to disease prevention and treatment, for instance by optimizing gender-specific dietary and pharmacological requirements. The study presented in this thesis was performed within the framework of Top Institute Food and Nutrition, within the GH002 project.
KW - slijm
KW - spijsverteringskanaal
KW - darmen
KW - muizen
KW - probiotica
KW - eilandjes van peyer
KW - colitis
KW - transcriptomen
KW - immunohistologie
KW - veroudering
KW - geslacht (sex)
KW - homeostase
KW - gezondheid
KW - ziekten
KW - mucus
KW - digestive tract
KW - intestines
KW - mice
KW - probiotics
KW - peyer patches
KW - colitis
KW - transcriptomes
KW - immunohistology
KW - senescence
KW - sex
KW - homeostasis
KW - health
KW - diseases
M3 - internal PhD, WU
SN - 9789462574892
PB - Wageningen University
CY - Wageningen
ER -