Mucin-bacterial interactions in the human oral cavity and digestive tract

M.M.N. Derrien, M.W.J. van Passel, J.H.B. van de Bovenkamp, R.G. Schipper, W.M. de Vos

Research output: Contribution to journalArticleAcademicpeer-review

260 Citations (Scopus)


Mucins are a family of heavily glycosylated proteins that are the major organic components of the mucus layer, the protective layer covering the epithelial cells in many human and animal organs, including the entire gastro-intestinal tract. Microbes that can associate with mucins benefit from this interaction since they can get available nutrients, experience physico-chemical protection and adhere, resulting an increased residence time. Mucin-degrading microorganisms, which often are found in consortia, have not been extensively characterized as mucins are high molecular weight glycoproteins that are hard to study because of their size, complexity, and heterogeneity. The purpose of this review is to discuss how advances in mucus and mucin research, and insight in the microbial ecology promoted our understanding of mucin degradation. Recent insight is presented in mucin structure and organization, the micro-organisms known to use mucin as growth substrate, with a specific attention on Akkermansia muciniphila, and the molecular basis of microbial mucin degradation owing to availability of genome sequences
Original languageEnglish
Pages (from-to)254-268
JournalGut Microbes
Issue number4
Publication statusPublished - 2010

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