Molecular genetic and physiologic background of the growth hormone-IGF-I axis in relation to breeding for growth rate and leanness in pigs

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    Abstract

    The GH-IGF-I axis is of major importance for the regulation of body growth and composition, and cellular proliferation and differentiation processes. Selective breeding aiming to improve growth rate and/or body composition is accompanied by changes of the GH-IGF-I axis. Research aiming to elucidate the genetic and physiologic mechanism(s) underlying these changes may best use single-trait selection lines. Two such pig selection lines, one for growth rate and one for high lean content, were used in experiments to investigate the mechanisms of the GH-IGF-I axis change during selection. This contribution reviews the selection-related changes in the GH-IGF-I axis as the consequences of selection for whole body growth rate or body composition and effects on local tissue growth rate. A model explaining the observed effects and consequences for the pressure on the physiology is presented. In short, selection related demand for GH induces GH synthesis until a limit is reached. After that the pulsatile GH plasma profile changes, which may also affect expression profiles of genes regulating body composition. (C) 2004 Elsevier Inc. All rights reserved.
    Original languageEnglish
    Pages (from-to)287-301
    JournalDomestic Animal Endocrinology
    Volume27
    Issue number3
    DOIs
    Publication statusPublished - 2004

    Keywords

    • messenger-rna expression
    • quantitative trait loci
    • factor binding-proteins
    • skeletal-muscle
    • porcine somatotropin
    • adipose-tissue
    • myogenin gene
    • satellite cells
    • pituitary-gland
    • finishing pigs

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