Molecular characterization and meta-analysis of gut microbial communities illustrate enrichment of prevotella and megasphaera in Indian subjects

Shrikant Bhute, Pranav Pande, Sudarshan A. Shetty, Rahul Shelar, Sachin Mane, Shreyas V. Kumbhare, Ashwini Gawali, Hemal Makhani, Mohit Navandar, Dhiraj Dhotre, Himangi Lubree, Dhiraj Agarwal, Rutuja Patil, Shantanu Ozarkar, Saroj Ghaskadbi, Chittaranjan Yajnik, Sanjay Juvekar, Govind K. Makharia, Yogesh S. Shouche*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

46 Citations (Scopus)

Abstract

The gut microbiome has varied impact on the wellbeing of humans. It is influenced by different factors such as age, dietary habits, socio-economic status, geographic location, and genetic makeup of individuals. For devising microbiome-based therapies, it is crucial to identify population specific features of the gut microbiome. Indian population is one of the most ethnically, culturally, and geographically diverse, but the gut microbiome features remain largely unknown. The present study describes gut microbial communities of healthy Indian subjects and compares it with the microbiota from other populations. Based on large differences in alpha diversity indices, abundance of 11 bacterial phyla and individual specific OTUs, we report inter-individual variations in gut microbial communities of these subjects. While the gut microbiome of Indians is different from that of Americans, it shared high similarity to individuals from the Indian subcontinent i.e., Bangladeshi. Distinctive feature of Indian gut microbiota is the predominance of genus Prevotella and Megasphaera. Further, when compared with other non-human primates, it appears that Indians share more OTUs with omnivorous mammals. Our metagenomic imputation indicates higher potential for glycan biosynthesis and xenobiotic metabolism in these subjects. Our study indicates urgent need of identification of population specific microbiome biomarkers of Indian subpopulations to have more holistic view of the Indian gut microbiome and its health implications.

Original languageEnglish
Article number660
JournalFrontiers in Microbiology
Volume7
Issue numberMAY
DOIs
Publication statusPublished - 2016

Keywords

  • 16S rRNA amplicon
  • Indian subjects
  • Prevotella and Megasphaera
  • QPCR

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    Bhute, S., Pande, P., Shetty, S. A., Shelar, R., Mane, S., Kumbhare, S. V., Gawali, A., Makhani, H., Navandar, M., Dhotre, D., Lubree, H., Agarwal, D., Patil, R., Ozarkar, S., Ghaskadbi, S., Yajnik, C., Juvekar, S., Makharia, G. K., & Shouche, Y. S. (2016). Molecular characterization and meta-analysis of gut microbial communities illustrate enrichment of prevotella and megasphaera in Indian subjects. Frontiers in Microbiology, 7(MAY), [660]. https://doi.org/10.3389/fmicb.2016.00660