Molecular biology. A Swiss army knife of immunity

S.J.J. Brouns

Research output: Contribution to journalEditorialAcademicpeer-review

6 Citations (Scopus)

Abstract

Selfish genetic elements are more than a daily nuisance in the life of prokaryotes. Whereas viruses can multiply by reprogramming host cells, or integrate in the host genome as “stowaways,” conjugative plasmids (transferrable extrachromosomal DNA) make cells addicted to plasmid-encoded antitoxin factors, thus preventing their disposal. Bacteria and archaea defend themselves against these invasive elements using an adaptive immune system based on clustered regularly interspaced short palindromic repeats (CRISPRs). On page 816 in this issue, Jinek et al. (1) show how the CRISPR effector enzyme Cas9 from bacteria is directed not by one, but two small RNAs to cleave invader DNA.
Original languageEnglish
Pages (from-to)808-809
JournalScience
Volume337
Issue number6096
DOIs
Publication statusPublished - 2012

Fingerprint

knives
molecular biology
plasmids
immunity
antitoxins
bacteria
DNA
Archaea
prokaryotic cells
RNA
cells
viruses
genome
enzymes
adaptive immunity

Keywords

  • streptococcus-thermophilus
  • small rnas
  • bacteria
  • dna
  • resistance
  • systems
  • archaea

Cite this

Brouns, S.J.J. / Molecular biology. A Swiss army knife of immunity. In: Science. 2012 ; Vol. 337, No. 6096. pp. 808-809.
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Molecular biology. A Swiss army knife of immunity. / Brouns, S.J.J.

In: Science, Vol. 337, No. 6096, 2012, p. 808-809.

Research output: Contribution to journalEditorialAcademicpeer-review

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AB - Selfish genetic elements are more than a daily nuisance in the life of prokaryotes. Whereas viruses can multiply by reprogramming host cells, or integrate in the host genome as “stowaways,” conjugative plasmids (transferrable extrachromosomal DNA) make cells addicted to plasmid-encoded antitoxin factors, thus preventing their disposal. Bacteria and archaea defend themselves against these invasive elements using an adaptive immune system based on clustered regularly interspaced short palindromic repeats (CRISPRs). On page 816 in this issue, Jinek et al. (1) show how the CRISPR effector enzyme Cas9 from bacteria is directed not by one, but two small RNAs to cleave invader DNA.

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KW - small rnas

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KW - resistance

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