Abstract
| Original language | English |
|---|---|
| Pages (from-to) | 808-809 |
| Journal | Science |
| Volume | 337 |
| Issue number | 6096 |
| DOIs | |
| Publication status | Published - 2012 |
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Keywords
- streptococcus-thermophilus
- small rnas
- bacteria
- dna
- resistance
- systems
- archaea
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Molecular biology. A Swiss army knife of immunity. / Brouns, S.J.J.
In: Science, Vol. 337, No. 6096, 2012, p. 808-809.Research output: Contribution to journal › Editorial › Academic › peer-review
TY - JOUR
T1 - Molecular biology. A Swiss army knife of immunity
AU - Brouns, S.J.J.
PY - 2012
Y1 - 2012
N2 - Selfish genetic elements are more than a daily nuisance in the life of prokaryotes. Whereas viruses can multiply by reprogramming host cells, or integrate in the host genome as “stowaways,” conjugative plasmids (transferrable extrachromosomal DNA) make cells addicted to plasmid-encoded antitoxin factors, thus preventing their disposal. Bacteria and archaea defend themselves against these invasive elements using an adaptive immune system based on clustered regularly interspaced short palindromic repeats (CRISPRs). On page 816 in this issue, Jinek et al. (1) show how the CRISPR effector enzyme Cas9 from bacteria is directed not by one, but two small RNAs to cleave invader DNA.
AB - Selfish genetic elements are more than a daily nuisance in the life of prokaryotes. Whereas viruses can multiply by reprogramming host cells, or integrate in the host genome as “stowaways,” conjugative plasmids (transferrable extrachromosomal DNA) make cells addicted to plasmid-encoded antitoxin factors, thus preventing their disposal. Bacteria and archaea defend themselves against these invasive elements using an adaptive immune system based on clustered regularly interspaced short palindromic repeats (CRISPRs). On page 816 in this issue, Jinek et al. (1) show how the CRISPR effector enzyme Cas9 from bacteria is directed not by one, but two small RNAs to cleave invader DNA.
KW - streptococcus-thermophilus
KW - small rnas
KW - bacteria
KW - dna
KW - resistance
KW - systems
KW - archaea
U2 - 10.1126/science.1227253
DO - 10.1126/science.1227253
M3 - Editorial
VL - 337
SP - 808
EP - 809
JO - Science
JF - Science
SN - 0036-8075
IS - 6096
ER -